Abstract
Over the past 30 years the area of reproductive problems and reproductive failure has assumed a greater proportion of the interest of clinicians, epidemiologists, teratologists, geneticists and toxicologists. Much has been learned about the reproductive risks of exposing pregnant women to drugs and chemicals and physical environmental agents. Both epidemiological and animal studies have assisted in understanding the mechanism of some of these reproductive toxicants and the actual risk of being exposed to these agents. There also has been great advances in the field of clinical and basic genetics so that we have a much better understanding of the impact of genetic disease and our ability to diagnose these disorders. We are also aware of the fact that each generation has a small proportion of genetic disease not due to inherited genetic traits, but due to new genetic disease resulting from mutations that occurred during the development of germ cell mutations that produce mature eggs and sperm. We are still in the early stages of understanding the process of mutation and are presently investigating the impact of environmental agents on the induction of mutations as well as the alteration of reproductive performance.
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Brent, R.L. (1994). Biological Factors Related to Male Mediated Reproductive and Developmental Toxicity. In: Olshan, A.F., Mattison, D.R. (eds) Male-Mediated Developmental Toxicity. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1877-8_20
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