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Influence of Intratracheal Perflubron Vapor on Lung Mechanics and Blood Gases

  • R. J. Houmes
  • B. Lachmann
  • N. S. Faithfull
  • W. Erdmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 361)

Abstract

Studies in adult animals with acute respiratory failure have demonstrated that intratracheal administration of perflubron (perfluorooctyl-bromide, Alliance Pharmaceutical Corp., San Diego, CA) improves PaO2 values [1]. However, data on perflubron administration in healthy animals showed a decrease in PaO2 values [2]. It is speculated that this decrease could originate from an elevation of surface tension in healthy animals, combined with the mechanical effect of perflubron moving in the lungs during ventilation. The aim of this study was to assess the effect of vaporized perflubron on blood gases and lung mechanics in healthy animals.

Keywords

Adult Animal Acute Respiratory Failure Healthy Animal Lung Mechanic Ventilatory Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Tűtűcnű AS, Lachmann B, Faithfull NS, Erdmann W. Dose dependent improvement of gas exchange by intratracheal Perflubron (perfluorooctylbromide) instillation in adult animals with acute respiratory failure. Adv Exp Med Biol 1992; 317:397–400.CrossRefGoogle Scholar
  2. 2.
    Fuhrman BP, Parczan PR, DeFrancisis M. Perfluorocarbon-associated gas exchange. Crit Care Med 1991; 19:712PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • R. J. Houmes
    • 1
  • B. Lachmann
    • 1
  • N. S. Faithfull
    • 2
  • W. Erdmann
    • 1
  1. 1.Department of AnesthesiologyErasmus UniversityRotterdamThe Netherlands
  2. 2.Department of Medical ResearchAlliance Pharmaceutical CorpSan DiegoUSA

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