Ischemia, Reperfusion, and White Blood Cell Function in the Microcirculation

  • G. W. Schmid-Schönbein
  • M. Suematsu
  • J. Barroso-Aranda
  • R. H. Chavez-Chavez
  • T. T. Yee
  • F. A. DeLano
  • B. W. Zweifach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 361)

Abstract

Even under normal physiological conditions, the presence of leukocytes in microvessels influences local flow field and perfusion. Entry of leukocytes into capillaries may temporarily interrupt red cell motion. In capillaries, leukocytes move with a lower velocity than red cells, which leads to accumulation of erythrocytes upstream of the leukocyte and a plasma region downstream. Leukocyte adhesion to the post-capillary endothelium may also reduce microvascular perfusion. Consequently leukocytes may cause elevation of whole organ resistance.

Keywords

Ischemia Explosive Xanthine 

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • G. W. Schmid-Schönbein
    • 1
  • M. Suematsu
    • 1
  • J. Barroso-Aranda
    • 1
  • R. H. Chavez-Chavez
    • 1
  • T. T. Yee
    • 1
  • F. A. DeLano
    • 1
  • B. W. Zweifach
    • 1
  1. 1.Institute for Biomedical EngineeringUniversity of California San DiegoLa JollaUSA

Personalised recommendations