Abstract
The Haldane effect (HE) is characterized by the binding of hydrogen ions and CO2 accompanying deoxygenation of hemoglobin (Hb) due to a negative heterotropic allosteric ligand interaction (Bauer, 1974; Siggaard-Andersen, 1974; Baumann et al., 1987). The binding sites of the oxygen-linked hydrogen ions have been mapped for adult hemoglobin (Perutz, 1970; Kilmartin, 1972), being in part responsible for the pH-differences between oxygenated and deoxygenated blood. The question arises whether structural differences of Hb, either among different mammalian species or during developmental life, may influence the quantity of the Haldane effect, at least within the limits of accuracy achieved by blood-gas and acid-base analysis in both basic research and clinical practice.
Keywords
- Base Excess
- Capillary Sample
- Adult Hemoglobin
- Haldane Effect
- Inverse Linear Correlation
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Kalhoff, H., Werkmeister, F., Kiwull-Schöne, H., Diekmann, L., Manz, F., Kiwull, P. (1994). The Haldane Effect Under Different Acid-Base Conditions in Premature and Adult Humans. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_55
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DOI: https://doi.org/10.1007/978-1-4615-1875-4_55
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