Alterations in Erythrocyte Deformability Under Hypoxia: Implications for Impaired Oxygen Transport
Oxygen delivery to the tissues requires that the erythrocyte be highly deformable in order to pass through the narrow pores of the capillary bed. It has been shown that oxidative damage produces crosslinking of hemoglobin with membrane proteins (Shaklai et al., 1987; Snyder et al., 1985; Reinhart et al., 1986) resulting in a more rigid, less deformable membrane. Hypoxia as a source for oxidative damage and thereby a possible loss in erythrocyte deformability is based on recent studies which indicated enhanced autoxidation and superoxide formation (Rifkind et al., 1989, 1991) within erythrocytes at intermediate oxygen pressures.
KeywordsHydrogen Peroxide Filtration Superoxide Electrophoresis Ghost
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