Site-Directed Mutagenesis of Rhizopuspepsin: An Analysis of Unique Specificity
Rhizopuspepsin is an aspartic proteinase from the fungus Rhizopus chinensis. Interest in rhizopuspepsin as a model system for studying active site interactions stems principally from the need to understand interactions which may be exploited in rational drug design. Targets for these therapeutics are renin, which plays a role in hypertension, the HIV proteinase, essential to the HIV life cycle, and a variety of related, secreted Candida yeast aspartic proteinases[1, 2].
KeywordsAspartic Proteinase Rational Drug Design Unique Specificity Porcine Pepsin Oklahoma Medical Research Foundation
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