Non-Mammalian Vertebrate Pepsinogens and Pepsins: Isolation and Characterization
Pepsinogen, the precursor of pepsin, is secreted from the gastric mucosa into the gastric lumen, where it is autocatalytically activated to pepsin under acidic conditions. It is classified into three major types, that is, pepsinogen A, pepsinogen C (or progastricsin), and prochymosin (or neonatal pepsinogen). Further, pepsinogens, especially pepsinogens A, are often composed of several isozymogens. So far, a number of pepsinogens were purified from various sources, characterized and sequenced at the protein level and/or DNA level. Thus the complete amino acid sequences of mammalian pepsinogens are known for human (1), monkey (2), porcine (3–6), and rabbit (7) pepsinogens A, human (8), monkey (9), rat (10) and guinea pig (11) pepsinogens C, and bovine prochymosin (12).
KeywordsGastric Mucosa Esophageal Mucosa Japanese Monkey Activation Segment Pacific Bluefin
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