Non-Mammalian Vertebrate Pepsinogens and Pepsins: Isolation and Characterization

  • Kenji Takahashi
  • Masao Tanji
  • Etsuko Yakabe
  • Akira Hirasawa
  • Senerath B. P. Athauda
  • Takashi Kageyama
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 362)


Pepsinogen, the precursor of pepsin, is secreted from the gastric mucosa into the gastric lumen, where it is autocatalytically activated to pepsin under acidic conditions. It is classified into three major types, that is, pepsinogen A, pepsinogen C (or progastricsin), and prochymosin (or neonatal pepsinogen). Further, pepsinogens, especially pepsinogens A, are often composed of several isozymogens. So far, a number of pepsinogens were purified from various sources, characterized and sequenced at the protein level and/or DNA level. Thus the complete amino acid sequences of mammalian pepsinogens are known for human (1), monkey (2), porcine (3–6), and rabbit (7) pepsinogens A, human (8), monkey (9), rat (10) and guinea pig (11) pepsinogens C, and bovine prochymosin (12).


Gastric Mucosa Esophageal Mucosa Japanese Monkey Activation Segment Pacific Bluefin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Kenji Takahashi
    • 1
  • Masao Tanji
    • 1
  • Etsuko Yakabe
    • 1
  • Akira Hirasawa
    • 1
  • Senerath B. P. Athauda
    • 1
  • Takashi Kageyama
    • 2
  1. 1.Department of Biophysics and BiochemistryThe University of TokyoTokyoJapan
  2. 2.Department of Cellular and Molecular Biology Primate Research InstituteKyoto UniversityInuyama, AichiJapan

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