A Minute Gastric Cancer Detected by a New Screening Method Using Serum Pepsinogen I and II
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 362)
A gastric cancer, despite a recent decline in the mortality rate, is still a leading cause of cancer death in Japan, so that considerable effort continues to be focused on the early detection of the cancer through mass screening programs throughout the country. In most workplaces, an indirect barium x-ray examination combined with endoscopic inspection has been the standard screening method used in Japan. However, this method has certain drawbacks in detecting early gastric cancers, for exsample due to the low sensitivity of the barium x-ray procedure, which is the first step of the screening process. Therefore, to improve the effectiveness of gastric cancer screening, we have established a new screening system that uses serum pepsinogen tests instead of the indirect barium x-ray method, since it has been found that the serum tests are better able to detect advanced stages of chronic atrophic gastritis  , which is thought to be a precancerous condition that lead to the development of gastric cancer. In 1991, the first gastric mass screening using this system was carried out in the workplace and here we report on the first case of minute gastric cancer detected by this new screening method.
KeywordsAdenocarcinoma Barium Gastritis
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