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A Minute Gastric Cancer Detected by a New Screening Method Using Serum Pepsinogen I and II

  • Masashi Matsushima
  • Kazumasa Miki
  • Masao Ichinose
  • Nobuyuki Kakei
  • Naohisa Yahagi
  • Masahiro Kido
  • Yasuhito Shimizu
  • Satoshi Ishihama
  • Shinko Tsukada
  • Kiyoshi Kurokawa
  • Kenji Takahashi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 362)

Abstract

A gastric cancer, despite a recent decline in the mortality rate, is still a leading cause of cancer death in Japan, so that considerable effort continues to be focused on the early detection of the cancer through mass screening programs throughout the country. In most workplaces, an indirect barium x-ray examination combined with endoscopic inspection has been the standard screening method used in Japan. However, this method has certain drawbacks in detecting early gastric cancers, for exsample due to the low sensitivity of the barium x-ray procedure, which is the first step of the screening process. Therefore, to improve the effectiveness of gastric cancer screening, we have established a new screening system that uses serum pepsinogen tests instead of the indirect barium x-ray method, since it has been found that the serum tests are better able to detect advanced stages of chronic atrophic gastritis [1] [2], which is thought to be a precancerous condition that lead to the development of gastric cancer. In 1991, the first gastric mass screening using this system was carried out in the workplace and here we report on the first case of minute gastric cancer detected by this new screening method.

Keywords

Gastric Cancer Early Gastric Cancer Chronic Atrophic Gastritis Gastric Cancer Case Serum Pepsinogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    K. Miki, M. Ichinose, A. Shimizu, et al., Serum pepsinogens as a screening test of extensive chronic gastritis, Gsatroenterol. Jpn. 22:133 (1987)Google Scholar
  2. 2.
    K. Miki, M. Ichimose, N. Kawamura, et al., The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects, Jpn. J. Cancer Res. 80:111 (1989)PubMedCrossRefGoogle Scholar
  3. 3.
    K. Miki, M. Ichimose, K.B. Ishikawa, et al., Clinical application of serum pepsinogen I and II levels for mass screening to detect gastric cancer, Jpn. J. Cancer Res. 84:1086 (1993)PubMedCrossRefGoogle Scholar
  4. 4.
    I. Kushner, W. Rapp, P. Brutin, et al. Electrophoretic and immunochemical demonstration of the existence of four human pepsinogens, J. Clin. Invest. 43:1983 (1964)PubMedCrossRefGoogle Scholar
  5. 5.
    I.M. Samloff, Pepsinogens, pepsins and pepsin inhibitors, Gastroenterology 60:586 (1971)PubMedGoogle Scholar
  6. 6.
    B.I. Hirschowitz, Pepsinogen; its origin, secretion and excretion, Physiol. Rev. 37:475 (1957)PubMedGoogle Scholar
  7. 7.
    O.A.A. Bock, G. Arapakis, L.J. Witts and C.D. Richards, The serum pepsinogen level with special reference to the histology of the stomach mucosa, Gut 4:106 (1963)PubMedCrossRefGoogle Scholar
  8. 8.
    I.M. Samloff, K. Varis, T. Ihamaki, M. Siurala and J.I. Rotter, Relationship among serum pepsiongen I, serum pepsinogen II and gastric mucosal histology, Gastroenterology 83:204 (1982)PubMedGoogle Scholar
  9. 9.
    P. Correa, The gastric precancerous process, Cancer Surveys 2:437 (1983)Google Scholar
  10. 10.
    T. Imai, T. Kubo and H. Watanabe, Chronic gastritis in Japanese with reference to high incidence of gastric carcinoma, J. Natl. Cancer Inst. 47:179 (1971)PubMedGoogle Scholar
  11. 11.
    R. Cheli, L. Simon, H. Aste, et al., Atrophic gastritis and intestinal metaplasia in asymptomatic Hungarian and Italian populations, Endoscopy 12:105 (1980)PubMedCrossRefGoogle Scholar
  12. 12.
    M. Ichinose, K. Miki, C. Furihata, et al., Radioimmunoassay of group II pepsinogens in human serum, Clin. Chim. Acta 122:61 (1982)PubMedCrossRefGoogle Scholar
  13. 13.
    M. Ichinose, K. Miki, C. Furihata, et al., Radioimmunoassay of group I and group II pepsinogens in normal controls and patients with various disorders, Clin. Chim. Acta 126:183 (1982)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Masashi Matsushima
    • 1
  • Kazumasa Miki
    • 1
  • Masao Ichinose
    • 1
  • Nobuyuki Kakei
    • 1
  • Naohisa Yahagi
    • 1
  • Masahiro Kido
    • 1
  • Yasuhito Shimizu
    • 1
  • Satoshi Ishihama
    • 1
  • Shinko Tsukada
    • 1
  • Kiyoshi Kurokawa
    • 1
  • Kenji Takahashi
    • 2
  1. 1.The First Department of Internal Medicine Faculty of MedicineUniversity of TokyoTokyoJapan
  2. 2.Department of Biophysics and Biochemistry Faculty of ScienceUniversity of TokyoTokyoJapan

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