Sympatho-Adrenergic Regulation of Duodenal Alkaline Secretion

  • Lars Fändriks
  • Claes Jönson
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 2)


Acid secreted by the gastric parietal cells is an important factor in the digestive process. The acidity is, however, a potential threat to the organism itself and several protective mechanisms are utilized to prevent autodigestion. Today, it is well established that there exists a bicarbonate secretion by the gastroduodenal surface epithelium which neutralizes gastric acid1,2. Micro-pH-electrodes have been used to demonstrate a pH-gradient immediately above the epithelial cells; pH at the cell surface being neutral despite highly acidic luminal contents3,4. In the duodenum, this transport of bicarbonate is probably the most important factor for protection against gastric acid, whereas it plays a more subordinate role in the stomach1,5.


Vagal Stimulation Splanchnic Nerve Total Blood Volume Bicarbonate Secretion Mucosal Protection 
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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Lars Fändriks
  • Claes Jönson

There are no affiliations available

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