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Cytochrome Biochemistry in Sheep Retina Following Exposure to Oxygen

  • R. Stockton
  • J. Wilhelm
  • D. Armstrong
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 366)

Abstract

The mitochondrial enzyme cytochrome c oxidase (COX) is abundant in the photoreceptor inner segments and the synaptic layers of the retina where it functions as essential enzyme in oxidative metabolism. Indeed, the neural retina has the highest known rates respiration and glucose oxidation (1,2). However, the greatest concentration of COX is found in the retinal pigment epithelium (RPE) where it presumably functions primarily as an antioxidant. Photoreceptor cells are highly sensitive to oxygen toxicity when oxygen tensions (PO2) are elevated by as little as two fold (3).The photoreceptor cell membrane is particularly susceptible to free radical attack because of its high ratio of docosahexaenoic acid (4). However O2 toxicity might be exacerbated by a direct effect of O2 upon the activity of COX which would diminish its efficiency in both its metabolic role and as an antioxidant.

Keywords

Retinal Pigment Epithelium Docosahexaenoic Acid Outer Segment Neural Retina Photoreceptor Outer Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • R. Stockton
    • 1
  • J. Wilhelm
    • 1
  • D. Armstrong
    • 1
  1. 1.Departments of Ophthalmology and Medical TechnologySUNYBuffaloUSA

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