Aging Associated Declines in the Antioxidant Enzymes of Human Testis
One potential factor in aging is a decline in antioxidant protection that would facilitate progressive accumulation of damage by reactive oxygen species. Testicular atrophy is commonly found in aged males but little is known about effects of aging on the antioxidant protection systems of human testis. Our first objective was to determine if aging was associated with changes in testicular activities of aldehyde dehydrogenase, GSSG reductase, and GSH peroxidase. Aldehyde dehydrogenase detoxifies malondialdehyde, 4-hydroxynonenal and related products of lipid peroxidation. GSH peroxidase detoxifies H2O2 and fatty acid peroxide product of lipid peroxidation. GSSG reductase regenerates GSSG to GSH. Our second objective was to determine if observed changes in antioxidant protection were associated with morphological characteristics of testicular atrophy.