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Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis

  • Mary Treinen Moslen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 366)

Abstract

This presentation will examine major processes by which biological systems cope with reactive oxygen species (ROS). Peroxidation of membrane lipids will be considered as one example of the destructive processes that occur when ROS are not controlled by the protection systems that detoxify reactive species. In contrast, enzymatic peroxidation of arachidonic acid initiates the biosynthesis of chemotactic leukotrienes. Phagocytic cell formation of ROS by the “oxidative burst” will be examined because of its important role in the defense against invading organisms. The focus will be on the processes that stringently control activation of the NADPH oxidase of phagocytic cells.

Keywords

Reactive Oxygen Species NADPH Oxidase Oxidative Burst Chronic Granulomatous Disease Phagocytic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mary Treinen Moslen
    • 1
  1. 1.Department of PathologyUniversity of Texas Medical BranchGalvestonUSA

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