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Free Radicals in the Pathophysiology of Pulmonary Injury and Disease

  • Daniel J. Brackett
  • Paul B. McCay
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 366)

Abstract

There is a substantial volume of literature indicating that free radicals are significantly involved in lung injury and disease in a wide variety of clinically relevant situations. Evidence to support this relationship is derived from both experimental animal studies and clinical studies of human patients. Data is convincing that pulmonary injury can be induced by a myriad of stimuli that have the capacity to activate the inflammatory system These stimuli initiate a cascade of events that appear to involve the inflammatory mediators complement, tumor necrosis factor, thromboxane, xanthine oxidase, neutrophils, and the subject of this chapter, free radicals. The conclusions of reports which have utilized manipulation of these mediators in experimental studies and measurements of indices of excessive free radical generation in patients suffering from pulmonary disorders strongly suggest that free radicals may be essential and perhaps final mediators of lung injury in many of these experimental and clinical situations. These data support further evidence that measurements detecting the presence of excessive free radical generation or cellular injury known to be associated with free radical reactions may be useful tools in revealing the potential for the development of pulmonary damage and as predictors of the intensity of the injury. Clinical measurements of this type may result in the identification of patients who are at high risk for pulmonary injury or disease and who are candidates for antioxidant therapy. This chapter will review a selection of reports from the literature documenting the significant role of free radicals in lung injury, their presence in pulmonary disease, and the potential for clinically relevant measurements of free radical generation and activity to aid in the detection, prediction, and therapy of damage to the pulmonary system.

Keywords

Cystic Fibrosis Lung Injury Acute Lung Injury Idiopathic Pulmonary Fibrosis Xanthine Oxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Daniel J. Brackett
    • 1
    • 2
    • 3
  • Paul B. McCay
    • 1
    • 3
  1. 1.Departments of Surgery and AnesthesiologyUniversity of Oklahoma Health Sciences CenterUSA
  2. 2.Veterans Affairs Medical CenterUSA
  3. 3.Free Radical Biology and Aging ProgramOklahoma Medical Research FoundationOklahoma CityUSA

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