Skip to main content

A Compendium of Vaccine Adjuvants and Excipients

  • Chapter

Part of the Pharmaceutical Biotechnology book series (PBIO,volume 6)

Abstract

In the early 20th century, researchers experimented with diverse compounds such as alum (aluminum salts), mineral oil, and killed mycobacteria to improve the immunogenicity of vaccines. These first empirical studies demonstrated the adjuvant activity of many substances, but several products also elicited significant local and systemic adverse reactions that precluded their use in human vaccine formulations. Alum adjuvant, first described in 1926, remains the only immunologic adjuvant used in human vaccines licensed in the United States.

Keywords

  • Vaccine Formulation
  • Vaccine Adjuvant
  • Adjuvant Activity
  • Adjuvant Property
  • Adjuvant Formulation

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-1-4615-1823-5_7
  • Chapter length: 88 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   74.99
Price excludes VAT (USA)
  • ISBN: 978-1-4615-1823-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Vogel, F.R., Powell, M.F. (1995). A Compendium of Vaccine Adjuvants and Excipients. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1823-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5737-7

  • Online ISBN: 978-1-4615-1823-5

  • eBook Packages: Springer Book Archive