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Vaccine Design pp 875–890Cite as

Development of Active Specific Immunotherapeutic Agents Based on Cancer-Associated Mucins

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Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

The immune system offers the most effective line of defense against infectious organisms. Cancer immunologists are currently attempting to direct the unique defense mechanisms of the immune system to mediate tumor rejection. This approach is based on the assumption that cancer cells express aberrant molecules that have the potential to be recognized by the immune system as “foreign.” If such cancer-specific targets can be identified, they may be used as active specific immunotherapeutic (ASI) agents to induce specific immune responses against the cells expressing such structures. Such responses may result in cancer rejection.

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Authors and Affiliations

  1. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2N8, Canada

    John Samuel

  2. Department of Immunology, Faculty of Medicine, University of Alberta, Edmonton, Canada

    B. Michael Longenecker

  3. Biomira Inc., Edmonton, Alberta, T6N 1H1, Canada

    B. Michael Longenecker

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  1. John Samuel
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Editors and Affiliations

  1. Genentech, Inc., South San Francisco, California, USA

    Michael F. Powell

  2. Vaxcel, Inc., Norcross, Georgia, USA

    Mark J. Newman

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Samuel, J., Longenecker, B.M. (1995). Development of Active Specific Immunotherapeutic Agents Based on Cancer-Associated Mucins. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_39

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  • Online ISBN: 978-1-4615-1823-5

  • eBook Packages: Springer Book Archive

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