Skip to main content
SpringerLink
Log in
Book cover

Vaccine Design pp 325–345Cite as

Liposomal Presentation of Antigens for Human Vaccines

  • Chapter

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

The increasing use of liposomes in biology and medicine has prompted a rigorous characterization of both classical multilamellar vesicle and novel liposome preparations. Drug delivery applications of liposomes or liposomes as immunological adjuvants have necessitated the production of large quantities of defined phospholipids of high purity, prompting a similar intensification of research. The growing interest in liposomes can be attributed to three major perspectives: (1) physicists and physical chemists take an interest in liposomes as a system in which forces between amphiphilic molecules can be studied; (2) biochemists, biophysicists, and scientists in related areas consider the liposome to be an appropriate model for biological membranes; (3) scientists in other disciplines including pharmaceutical and agricultural industries are interested in the potential use of liposomes as carriers (vehicles) for the application of drugs, vaccines, insecticides, fertilizers, and genetic materials. The growing interest of industries has promoted the production of specific instrumentation for the scaleup of liposome production.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Air, G. M., and Laver, W. G., 1989, The neuraminidase of influenza virus, Proteins 6:341–356.

    Article  PubMed  CAS  Google Scholar 

  • Allison, A.C., and Gregoriadis, G., 1974, Liposomes as immunological adjuvants, Nature 252:252–255.

    Article  PubMed  CAS  Google Scholar 

  • Alpar, H. O., Bowen, J. C., and Brown, M. R. W., 1992, Effectiveness of liposomes as adjuvants of orally and nasally administered tetanus toxoid, Int. J. Pharmacol. 88:335–344.

    Article  CAS  Google Scholar 

  • Althaus, B., and Glück, R., 1993, Clinical experience with the first liposomal hepatitis A vaccine, Abstract, in: International Symposium on Viral Hepatitis and Liver Disease, Tokyo.

    Google Scholar 

  • Alving, C. R., 1992, Immunologic aspects of liposomes, Presentation and processing of liposomal protein and phospholipid antigens, Biochim. Biophys. Acta, 1113:307–322.

    Article  PubMed  CAS  Google Scholar 

  • Alving, C. R., and Richards, R. L., 1990, Liposomes containing lipid A: A potent nontoxic adjuvant for a human malaria sporozoite vaccine, Immunol. Lett. 25:275–280.

    Article  PubMed  CAS  Google Scholar 

  • Alving, G. R., Wassef, N. M., Verma, J. N., Richard, R. L., Atkinson, C. T., and Aikawa, M., 1992, Liposomes as vehicles for vaccines — Intracellular fate of liposomal antigen in macrophages, Biochim. Biophys. Acta 1113:307–322.

    Article  PubMed  CAS  Google Scholar 

  • Antimisiaris, S. G., Jayasekera, P., and Gregoriadis, G., 1993, Liposomes as vaccine carriers — Incorporation of soluble and paniculate antigens in giant vesicles, J. Immunol. Methods 166:271–280.

    Article  PubMed  CAS  Google Scholar 

  • Ashley, H., and Ovary, Z., 1965, Effect of bovine gamma globulin on subsequent immunization with dinitrophenylated bovine gamma globulin, Proc. Soc. Exp. Biol. Med. 119:311–314.

    PubMed  CAS  Google Scholar 

  • Bangham, A. D., 1961, A correlation between surface charge and coagulant action of phospholipids, Nature 192:1197–1198.

    Article  PubMed  CAS  Google Scholar 

  • Bangham, A. D., 1968, Membrane models with phospholipids, Prog. Biophys. Mol. Biol. 18:29–37.

    Article  CAS  Google Scholar 

  • Bangham, A. D., Standish, M. M., and Watkins, J. C., 1965, Diffusion of univalent ions across the lamellae of swollen phospholipids, J. Mol. Biol. 13:238–252.

    Article  PubMed  CAS  Google Scholar 

  • Bangham, A. D., Hill, M. W., and Miller, N. G. A., 1974, Preparation and use of liposomes as models of biological membranes, in: Methods in Membrane Biology (E. D. Korn, ed.), Plenum Press, New York, pp. 1–23.

    Chapter  Google Scholar 

  • Blum, J. S., and Cresswell, P., 1988, Role for intracellular proteases in the processing and transport of class II HLA antigens, Proc. Natl. Acad. Sci. USA, 85:3975–3979.

    Article  PubMed  CAS  Google Scholar 

  • Bredehorst, R., Ligler, F. S., Kusterbeck, A. W., Chang, E. L., Gaber, B. P., and Vogel, L.-W., 1986, Effect of covalent attachment of immunoglobulin fragments on liposomal integrity, Biochemistry 25:5693–5699.

    Article  PubMed  CAS  Google Scholar 

  • Brotherus, J. R., Griffith, O. H., and Brotherus, M. O., 1981, Lipid-protein multiple binding equilibria, Biochemistry 20:5261–5267.

    Article  PubMed  CAS  Google Scholar 

  • Brunner, J., 1989, Testing topological models for the membrane penetration of the fusion peptide of influenza virus hemagglutinin, FEBS Lett. 57:369–372.

    Article  Google Scholar 

  • Buiting, A. M. J., van Rooijen, N., and Ciaassen, E., 1992, Liposomes as antigen carriers and adjuvants in vivo, Res. Immunol. 143:541–548.

    Article  PubMed  CAS  Google Scholar 

  • Cserkáti, T., and Szögyi, M., 1991, Interaction of phospholipids with proteins, peptides and amino acids. New advances 1987–1989, Int. J. Biochem. 23:131–145.

    Article  Google Scholar 

  • Davidson, R. N., Croft, S. L., and Scott, A., 1991, Liposomal amphotericin B in drug resistant visceral leishmaniasis, Lancet 337:1061–1062.

    Article  PubMed  CAS  Google Scholar 

  • Dean, T., 1993, Liposomes in allergy and immunology, Clin. Exp. Allergy 23:557–563.

    Article  PubMed  CAS  Google Scholar 

  • Duzzqunes, N., and Papahadjopoulos, D., 1983, Ionotropic effects on phospholipid membranes: Calcium/magnesium specificity in binding, fluidity and fusion, in: Membrane Fluidity in Biology (R. C. Aloia, ed.), Academic Press, New York, pp. 187–197.

    Google Scholar 

  • Eng, R. S., Pomerantz, R. J., and Friedman, L. S., 1993, Hepatitis A vaccines: Past, present, and future, Gastroenterology 105:943–945.

    PubMed  CAS  Google Scholar 

  • Fogler, W. E., Schwartz, G. M., Jr., and Alving, C. R., 1987, Antibodies to phospholipids and liposomes, Biochim. Biophys. Acta 903:265–272.

    Article  PubMed  CAS  Google Scholar 

  • Friede, M., Muller, S., Briand, J.-P., Van Regenmortel, M. H. V., and Schuber, F., 1993, Induction of immune response against a short synthetic peptide antigen coupled to small neutral liposomes containing monophosphoryl lipid A, Mol. Immunol. 30:539–547.

    Article  PubMed  CAS  Google Scholar 

  • Fries, L. F., Gordon, D. M., Richards, R. L., Egan, J. E., Hollingdale, M. R., Gross, M., Silverman, C., and Alving, C. R., 1992, Liposomal malaria vaccine in humans: A safe and potent adjuvant strategy, Proc. Natl. Acad. Sci. USA 89:358–362.

    Article  PubMed  CAS  Google Scholar 

  • Frösner, G. G., Dathe, O., Althaus, B., Glück, R., Erhardt, F., Eisenburg, J., Phillip, J., Heun, M., and Fröhlich, C., 1994, Hohe Immunogenität und geringe Nebenwirkungen eines neuartigen Liposomenimpfstoffes gegen Hepatitis A, in: Virushepatitis A bis E (G. Maass, and B. Stück, eds.), Kilian Verlag, pp. 222-224.

    Google Scholar 

  • Frösner, G. G., Herzog, C., and Glück, R., 1995, Efficacy of an inactivated virosome hepatitis A vaccine in children in a highly endemic country (in preparation).

    Google Scholar 

  • Garçon, N. M., and Six, H. R., 1991, Universal vaccine carrier. Liposomes that provide T-dependent help to weak antigen, J. Immunol. 146:3697–3702.

    PubMed  Google Scholar 

  • Garnier, F., Forquet, F., Bertolino, P., and Gerlier, D., 1991, Enhancement of in vivo and in vitro T-cell response against measles virus hemagglutinin after its incorporation into liposomes: Effect of the phospholipid composition, Vaccine 9:340–345.

    Article  PubMed  CAS  Google Scholar 

  • Glück, R., 1992, Immunopotentiating reconstituted influenza virosomes (IRIVs) and other adjuvants for improved presentation of small antigens, Vaccine 10:915–919.

    Article  PubMed  Google Scholar 

  • Glück, R., 1993, Towards a universal IRIV traveller vaccine, in: Third Conference on International Travel Medicine, Paris (April, 1993), Abstract No. 259.

    Google Scholar 

  • Glück, R., Althaus, B., Berger, R., Just, M, and Cryz, S. J., 1992a, Development, safety and immunogenicity of new inactivated hepatitis A vaccines: Effect of adjuvants, in: Travel Medicine 2 (H. O. Lobel, R. Steffen, and P. E. Kozarsky, eds.), International Society of Travel Medicine, pp. 135-136.

    Google Scholar 

  • Glück, R., Mischler, R., Brantschen, S., Just, M., Althaus, B., and Cryz, S. J., Jr., 1992b, Immunopotentiating reconstituted influenza virosome (IRIV) vaccine delivery system for immunization against hepatitis A, J. Clin. Invest. 90:2491–2495.

    Article  PubMed  Google Scholar 

  • Glück, R., Mischler, R., Finkel, B., Que, J. U., Scarpa, B., and Cryz, S. J., Jr., 1994, Immunogenicity of new virosome influenza vaccine in elderly people, Lancet 344:160–163.

    Article  PubMed  Google Scholar 

  • Goodman-Snitkoff, G., Good, M. F., Berzofsky, J. A., and Mannino, R. J., 1991, Role of intrastructural/intermolecular help in immunization with peptide-phospholipid complexes, J. Immunol. 147:410–415.

    PubMed  CAS  Google Scholar 

  • Gregoriadis, G., 1990, Immunological adjuvants: A role for liposomes, Immunol. Today 11:89–97.

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G., and Leathwood, P. D., 1971, Enzyme entrapment in liposomes, FEBS Lett. 14:95–99.

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G., Davis, J., and Davis, A., 1987, Liposomes as immunological adjuvants. Antigen incorporation studies, Vaccine 5:145–151.

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G., Wang, Z., Barenholz, Y., and Francis, M. J., 1993a, Liposome-entrapped T-cell peptide provides help for a co-entrapped B-cell peptide to overcome genetic restriction in mice and induce immunological memory, Immunology 80:535–540.

    PubMed  CAS  Google Scholar 

  • Gregoriadis, G., Garçon, N., Da Silva, H., and Sternberg, B., 1993b, Coupling of ligands to liposomes independently of solute entrapment: Observations on the formed vesicles, Biochim. Biophys. Acta 1147:185–190.

    Article  PubMed  CAS  Google Scholar 

  • Gregory, R. L., Michalek, S. M., Richardson, G., Harmon, C., Hilton, T., and McThee, J. R., 1986, Characterization of immune response to oral administration of Streptococcus sobrium ribosomal preparation in liposomes, Infect. Immun. 54:780–786.

    PubMed  CAS  Google Scholar 

  • Gupta, R. K., Relyveld, E. H., Lindblad, E. B., Bizzini, B., Ben-Efraim, S., and Kanta Gupta, C., 1993, Adjuvants — A balance between toxicity and adjuvanticity, Vaccine 11:293–306.

    Article  PubMed  CAS  Google Scholar 

  • Hafeman, D. G., Lewis, T. J., and McConnel, H. M., 1980, Triggering of the macrophage and neutrophil respiratory burst by antibody bound to a spin-label phospholipid hapten in model lipid bilayer membranes, Biochemistry 19:5387–5394.

    Article  PubMed  CAS  Google Scholar 

  • Harding, C. V., Collins, D. S., Slot, J. W., Geuze, H. J., and Unanue, E. R., 1991, Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells, Cell 64:393–401.

    Article  PubMed  CAS  Google Scholar 

  • Harter, C., James, P., Bachi, T., Semenza, G., and Brunner, J., 1989, Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the “fusion peptide,” J. Biol. Chem. 264:6459–6464.

    PubMed  CAS  Google Scholar 

  • Heath, T. D., Edwards, D. L., and Ryman, B. E., 1976, The adjuvant properties of liposomes, Biochem. Soc. Trans. 4:129–138.

    PubMed  CAS  Google Scholar 

  • Holzer, B. R., Hatz, C., Smith, D., Sissolak, R., Glück, R., and Egger, M., 1994, Immunogenicity and side effects of IRIV versus A1(OH)3 hepatitis A vaccine: A randomized controlled trial, Abstract, in: Assemblée annuelle commune de la Société Suisse de Médecine Intensive et de la Société Suisse d’Infectiologie, Lausanne, September 8–9, 1994.

    Google Scholar 

  • Honegger, J. L., Isakron, P. C., and Kinsky, S. C., 1980, Murine immunogenicity of N-substituted phosphatidylethanolamine derivatives in liposomes: Response to the hapten phosphocholine, J. Immunol. 124:669–675.

    PubMed  CAS  Google Scholar 

  • Israelachvili, J. N., Marcelja, S., and Horn, R. G., 1980, Physical principles of membrane organization, Q. Rev. Biophys. 13:121–200.

    Article  PubMed  CAS  Google Scholar 

  • Just, M., 1993, Experience with IRIV as carrier for hepatitis A and other antigens, Abstract No. 277, in: Third Conference on International Travel Medicine, Paris (April, 1993).

    Google Scholar 

  • Just, M., Berger, R., Drechsler, H., Brantschen, S., and Glück, R., 1992, A single vaccination with an inactivated hepatitis A liposome vaccine induces protective antibodies after only two weeks, Vaccine 10/11:737–739.

    Article  Google Scholar 

  • Kirby, C., and Gregoriadis, G., 1984, Dehydration-rehydration vesicles (DRV): A new method for high yield drug entrapment in liposomes, Biotechnology 2:979–984.

    Article  CAS  Google Scholar 

  • Kramp, W. J., Six, H. R., and Kasel, J. A., 1982, Post-immunization clearance of liposome-entrapped adenovirus type 5 hexon, Proc. Soc. Exp. Biol. Med. 169:135–139.

    PubMed  CAS  Google Scholar 

  • Lam, S. C. T., Plow, E. E., and Ginsberg, M. H., 1989, Platelet membrane glycoprotein II h heavy chain forms a complex with glycoprotein III a that binds Arg-Gly-Asp peptides, Blood 73:1513–1518.

    PubMed  CAS  Google Scholar 

  • Latif, N. A., and Bachhavat, B. K., 1988, The effect of surface-coupled antigen of liposomes in immunopotentiation, Immunol. Lett. 15:45–51.

    Article  Google Scholar 

  • Lawman, M. J. P., Naylar, P. T., Huang, L., Courtney, R. J., and Rouse, B. T., 1981, Cell-mediated immunity to herpes simplex virus: Induction of cytotoxic T-lymphocyte response by viral antigens incorporated into liposomes, J. Immunol. 126:304–308.

    PubMed  CAS  Google Scholar 

  • Lifshitz, R., Gitler, C., and Mozes, E., 1981, Liposomes as immunological adjuvants in eliciting antibodies specific to the synthetic Polypeptide poly (L-Tyr, L-Glu)-poly (DL-Ala)-poly (L-Lys) with high frequency of site-associated idiotypic determinants, Eur. J. Immunol. 11:398–410.

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Berestein, G., 1989, Treatment of systemic fungal infections with liposomal amphotericin B, in: Liposomes in the Therapy of Infectious Diseases and Cancer (G. Lopez-Berestein and I. J. Fidler, eds.), Liss, New York, pp. 317–327.

    Google Scholar 

  • Loutan, L., Bovier, P., Althaus, B., and Glück, R., 1994, Inactivated virosome hepatitis A vaccine, Lancet 343:322–324.

    Article  PubMed  CAS  Google Scholar 

  • Lowell, G. H., 1990, Proteosomes, hydrophobic anchors, iscoms and liposomes for improved presentation of peptide and protein vaccines, in: New Generation Vaccines (G. C. Woodrow and M. M. Levine, eds.), Dekker, New York, pp. 141–160.

    Google Scholar 

  • Lüscher-Mattli, M., and Glück, R., 1990, Dextran sulfate inhibits the fusion of influenza virus with model membranes, and suppresses influenza virus replication in vivo, Antiviral Res. 14:39–50.

    Article  PubMed  Google Scholar 

  • Lüscher-Mattli, M., Glück, R., Kempf, C, and Zanoni-Grassi, M., 1993, A comparative study of the effect of dextran sulfate on the fusion and the in vitro replication of influenza A and B, Semliki Forest, vesicular stomatitis, rabies, Sendai and mumps virus, Arch. Virol. 130:317–326.

    Article  PubMed  Google Scholar 

  • Manesis, E. K., Cameron, C. H., and Gregoriadis, G., 1979, Hepatitis B surface antigen-containing liposomes enhance humoral and cell-mediated immunity to the antigen, FEBS Lett. 102:107–111.

    Article  PubMed  CAS  Google Scholar 

  • Martin, F. J., and Papahadjopoulos, D., 1982, Irreversible coupling of immunoglobulin fragments to preformed vesicles: An improved method for liposome targeting, J. Biol. Chem. 257:286–288.

    PubMed  CAS  Google Scholar 

  • Martin, F. J., Hubbell, W. L., and Papahadjopoulos, D., 1981, Immunospecific targeting of liposomes to cells, Biochemistry 20:4229–4238.

    Article  PubMed  CAS  Google Scholar 

  • Matlin, K. S., Reggio, H., Helenius, A., and Simmons, K., 1981, Infection entry pathway of influenza virus in a canine kidney cell line, J. Cell. Biol. 91:601–613.

    Article  PubMed  CAS  Google Scholar 

  • Mayoral, J. L., Loeffler, C. M., Ochoa, A., and Dunn, D. L., 1990, Liposomal interleukin-2 (IL-2) a potential clinical vaccine adjuvant, in: Abstracts of the First Congress of the International Endotoxin Society, San Diego (May 1990), p. 67.

    Google Scholar 

  • Mengiardi, B., 1994, Virosomen als Träger von Kombinationsimpfstoffen. Inauguraldissertation, Universitätskinderklinik Basel, Mediz. Fakultät der Universität Basel.

    Google Scholar 

  • Morein, B., Helenius, A., Simons, K., Petterson, R., Kääriäinen, L., and Schirrmacher, V., 1978, Effective subunit vaccines against an enveloped virus, Nature 276:715–718.

    Article  PubMed  CAS  Google Scholar 

  • Müller-Eberhard, H. J., 1988, Molecular organization and function of the complement system, Annu. Rev. Biochem. 57:321–347.

    Article  PubMed  Google Scholar 

  • Neefjes, J. J., and Ploegh, H. L., 1992, Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistant alpha/beta heterodimers in endosomes, EMBO J. 11:411–416.

    PubMed  CAS  Google Scholar 

  • Neefjes, J. J., Stoollorz, V., Peters, P. J., Geuze, H. J., and Ploegh, H. L., 1990, The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytotic route, Cell 61:171–183.

    Article  PubMed  CAS  Google Scholar 

  • Ohsawa, T., Miura, H., and Harada, K., 1985, Evaluation of a new liposome preparation technique, the freeze-thawing method, using L-asparaginase as a model drug, Chem. Pharm. Bull. 33:2916–2923.

    Article  PubMed  CAS  Google Scholar 

  • Papahadjopoulos, D., 1974, Cholesterol and cell membrane functions: A hypothesis concerning the etiology of arteriosclerosis, J. Theor. Biol. 43:329–337.

    Article  PubMed  CAS  Google Scholar 

  • Papahadjopoulos, D., Hougie, C, and Hanacham, D. J., 1962, Influence of surface charge of phospholipids on their clot-promoting activity, Proc. Soc. Exp. Biol. Med. 111:412–416.

    CAS  Google Scholar 

  • Papahadjopoulos, D., Maykew, E., Poste, G., Smith, S., and Vail, W. J., 1974, Incorporation of lipid vesicles by mammalian cells provides a potential method for modifying cell behavior, Nature 252:163–165.

    Article  PubMed  CAS  Google Scholar 

  • Perrin, P., Thibodeau, L., Dauguet, C, Fritsch, A., and Sureau, P., 1984, Amplification des propriétés immunogènes de la glycoprotéine rabique par ancrage sur des liposomes préformés, Ann. Virol. (Inst. Pasteur) USE: 183-199.

    Google Scholar 

  • Peters, P. J., Neefjes, J. J., Oorschot, V., Ploegh, H. J., and Geuze, H. J., 1991, Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments, Nature 115:1213–1223.

    Google Scholar 

  • Phillips, N. C, and Emili, A., 1992, Enhanced antibody response to liposome-associated protein antigens: Preferential stimulation of IgG 2a/b production, Vaccine 10:151–158.

    Article  PubMed  CAS  Google Scholar 

  • Pieters, J., Horstmann, H., Bakke, O., Griffiths, G., and Lipp, J., 1991, Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain, J. Cell Biol. 115:1213–1223.

    Article  PubMed  CAS  Google Scholar 

  • Poovorawan, Y, Tieamboonlers, A., Chundermpadetsuk, S., Glück, R., and Cryz, S. J., 1994, Control of a hepatitis A outbreak by active immunization of high-risk susceptible subjects, J. Infect. Dis. 169:228–229.

    Article  PubMed  CAS  Google Scholar 

  • Rietjens, J. M. C. M., Anchor, L. J., and Veager, C, 1989, On the role of phospholipids in the reconstituted cytochrome P-450 system. A model study using dilaureyl and distearoyl glycerophosphocholine, Eur. J. Biochem. 181:309–316.

    Article  PubMed  CAS  Google Scholar 

  • Roche, P. A., and Cresswell, P., 1990, Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding, Nature 348:36–44.

    Google Scholar 

  • Sanchez, Y., Ionescu-Matiu, J., Dreesman, G. R., Kramp, W., Six, H. R., Hollinger, F. B., and Melnick, J. L., 1980, Humoral and cellular immunity to hepatitis B virus-derived antigens: Comparative activity of Freund complete adjuvant, alum and liposomes, Infect. Immun. 30:728–733.

    PubMed  CAS  Google Scholar 

  • Sarkar, D. P., Das, P. K., Bachhawat, B. K., and Das, M. K., 1982, The adjuvant effect of liposomes in eliciting anti-galactosyl antibodies, Immunol. Commun. 11:175–179.

    PubMed  CAS  Google Scholar 

  • Seganti, L., Superti, F., Orsini, N., Gabrielli, R., Divizia, M., and Panà, A., 1989, Membrane lipid components interacting with hepatitis A virus, Microbiologica 12:225–230.

    PubMed  CAS  Google Scholar 

  • Shahum, E., and Thérien, H.-M., 1988, Immunopotentiation of the humoral response by liposomes: Encapsulation versus covalent linkage, Immunology 65:315–317.

    PubMed  CAS  Google Scholar 

  • Shek, P. N., and Heath, T. D., 1983, Immune response mediated by liposome-associated protein antigens, Immunology 50:101–107.

    PubMed  CAS  Google Scholar 

  • Shek, P. N., and Sabiston, B. H., 1982, Immune response mediated by liposome-associated protein antigens. II. Comparison of the effectiveness of vesicle-entrapped and surface-associated antigen in immunopotentiation, Immunology 41:611–631.

    Google Scholar 

  • Shek, P. N., Yung, B. Y. K., and Stanacev, N. Z., 1983, Comparison between multilamellar and unilamellar liposomes in enhancing antibody formation, Immunology 49:37–42.

    PubMed  CAS  Google Scholar 

  • Small, D. M., and Shipley, G. G., 1974, Physical-chemical basis of the lipid deposition in arteriosclerosis, Science 185:222–229.

    Article  PubMed  CAS  Google Scholar 

  • Thérien, H.-M., Lair, D., and Shahum, E., 1990, Liposomal vaccine: Influence of antigen association on the kinetics of the humoral response, Vaccine 8:558–562.

    Article  PubMed  Google Scholar 

  • Treat, J., Greenspan, A., and Trost, D., 1990, Antitumour activity of liposome-encapsulated doxorubicin in advanced breast cancer: Phase II study, J. Natl. Cancer Inst. 82:1706–1710.

    Article  PubMed  CAS  Google Scholar 

  • Trudel, M., Nadon, F., Comtois, R., Ravacarinoro, M., and Payment, P., 1982, Antibody response to rubella virus proteins in different physical forms, Antiviral Res. 2:347–352.

    Article  PubMed  CAS  Google Scholar 

  • Tsurudome, M., Glück, R., Graf, R., Falchetto, R., Schaller, U., and Brunner, J., 1992, Lipid interactions of the hemagglutinin HA2NH2-terminal segment during influenza virus-induced membrane fusion, J. Biol. Chem. 267:20225–20232.

    PubMed  CAS  Google Scholar 

  • Tyrrel, D. A., Heath, T. D., Celley, C. M., and Ryman, B. E., 1976, New aspects of liposomes, Biochim. Biophys. Acta 457:229–235.

    Google Scholar 

  • Vannier, W. E., and Snyder, S. L., 1988, Antibody response to liposome associated antigen, Immunol. Lett. 19:59–67.

    Article  PubMed  CAS  Google Scholar 

  • Van Rooijen, N., and van Nieuwmegen, R., 1983a, Use of liposomes as biodegradable and harmless adjuvants, Methods Enzymol. 93:83–89.

    Article  PubMed  Google Scholar 

  • Van Rooijen, N., and van Nieuwmegen, R., 1983b, Association of an albumin antigen with phosphatidylcholine liposomes alters the nature of immunoglobulins produced during the immune response against the antigen, Biochim. Biophys. Acta 755:434–440.

    Article  PubMed  Google Scholar 

  • Wachsmann, D., Klein, J. P., Schaller, M., Ogier, J., Ackermann, F., and Frank, R. M., 1986, Serum and salivary antibody response in rats orally immunized with Streptococcus mutans carbohydrate protein conjugate associated with liposomes, Infect. Immun. 52:408–413.

    PubMed  CAS  Google Scholar 

  • Wälti, E., and Glück, R., 1993, Virosomes: Anew specific drug delivery system for cancer therapy, J. Mol. Recogn. 6(1):21.

    Google Scholar 

  • Wegmann, A., Zellmeyer, M., Glück, R., Finkel, B., Flückiger, A., Berger, R., and Just, M., 1994, Immunogenicity and stability of an alumfree liposomal hepatitis A vaccine, Schweiz. Med. Wochenschr. 124:2053–2056.

    PubMed  CAS  Google Scholar 

  • Wetzler, L. M., Blake, M. S., Barry, K., and Gotschlich, E. C., 1992, Gonococcal porin vaccine evaluation: Comparison of Por proteosomes, liposomes and blebs isolated from rmp depletion mutants, J. Infect. Dis. 166:551–555.

    Article  PubMed  CAS  Google Scholar 

  • Wieslander, A., and Seltsam, E., 1987, Acyl-chain-dependent incorporation of chlorophyll and cholesterol in membranes of Acholeplasma laidlawii, Biochim. Biophys. Acta 901:250–254.

    Article  CAS  Google Scholar 

  • Wiley, D. C., and Skehel, J. J., 1987, The structure and function of the hemagglutinin membrane glycoprotein of influenza virus, Annu. Rev. Biochem. 56:365–394.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Virology, Swiss Serum and Vaccine Institute Bern, CH-3001, Bern, Switzerland

    Reinhard Glück

Authors
  1. Reinhard Glück
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Genentech, Inc., South San Francisco, California, USA

    Michael F. Powell

  2. Vaxcel, Inc., Norcross, Georgia, USA

    Mark J. Newman

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Glück, R. (1995). Liposomal Presentation of Antigens for Human Vaccines. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1823-5_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5737-7

  • Online ISBN: 978-1-4615-1823-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation