Abstract
CDC2 has been shown to regulate entry into mitosis in eukaryotic cells. However, in Aspergillus nidulans, activation of CDC2 itself is not sufficient to trigger mitosis if another mitotic protein kinase, NIMA, is not activated. Superficially, NIMA and CDC2 have analogous functions and are regulated in a similar manner. NIMA activity is tightly regulated during the cell cycle. Overexpression of NIMA induces germinal vesicle breakdown in Xenopus oocytes and promotes premature entry into mitosis in all eukaryotic cells examined, whereas dominant-negative mutant NIMA causes a specific G2 arrest in Aspergillus nidulans and human cells, as is the case for CDC2. However, NIMA and CDC2 have quite distinct primary sequence substrate specificities. Furthermore, the regulatory mechanisms that govern the cell cycle-dependent abundance, activity and localization are largely intramolecular for NIMA but intermolecular for CDC2. More importantly, a NIMA-like pathway is also required for the G2/M transition in vertebrate cells. Thus, NIMA may represent a new essential eukaryotic cell cycle regulator, although its homologues in other species are yet to be identified.
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References
Nurse, P. (1994) Cell 79, 547–550.
Heichman, K.A. and Roberts, J.M. (1994) Cell 79, 557–562.
King, R.W., Jackson, P.K. and Kirschner, M.W. (1994) Cell 79, 563–571.
Sorger, P.K. and Murray, A.W. (1992) Nature 355, 365–368.
Amon, A., Surana, U., Muroff, I. and Nasmyth, K. (1992) Nature 355, 368–371.
Stueland, C.S., Lew, D.J., Cismowski, M.J. and Reed, S.I. (1993) Mol. Cell. Biol. 13, 3744–3755.
Osmani, A.H., McGuire, S.L. and Osmani, S.A. (1991) Cell 67, 283–291.
Choi, T., Aoki, F., Mori, M., Yamashita, M., Nagahama, Y. and Kohmoto, K. (1991) Development 113, 789–795.
Jung, T., Moor, R.M. and Fulka, J.J. (1993) Int. J. Dev. Biol. 37, 595–600.
Gavin, A.C., Cavadore, J.C. and Schorderet, S.S. (1994) J. Cell Sci. 275–283.
Osmani, S.A., Pu, R.T. and Morris, N.R. (1988) Cell 53, 237–244.
Osmani, S.A., May, G.S. and Morris, N.R. (1987) J. Cell Biol. 104, 1495–1504.
Osmani, A.H., O’Donnell, K., Pu, R.T. and Osmani, S.A. (1991) EMBO J. 10, 2669–2679.
Lu, K.P. and Means, A.R. (1994) EMBO J. 13, 2103–2113.
Lu, K.P., Osmani, S.A. and Means, A.R. (1993) J. Biol. Chem. 268, 8769–8776.
Lu, K.P., Kemp, B.E. and Means, A.R. (1994) J. Biol. Chem. 269, 6603–6607.
Songyang, Z., Lu, K.P., Blechner, S., Filhol, O., Cochet, C., Soderling, T.R., Bartleson, C., Graves, D.J., Blenis, J., Hunter, T. and Cantley, L.C. (1995) manuscript submitted.
Nigg, E.A. (1993) Curr. Opin. Cell Biol. 5, 187–193.
Lu, K.P. and Hunter, T. (1995) Cell 81, 413–424.
Timberlake, W.E. and Marshall, M.A. (1989) Science 244, 1313–1317.
Waring, R.B., May, G.S. and Morris, N.R. (1989) Gene 79, 119–130.
Lu, K.P. and Means, A.R. (1992) Methods Mol. Genet. 2, 255–275.
Morris, N.R., Osmani, S.A., Engle, D.B. and Doonan, J.H. (1989) Bioessays 10, 196–201.
Bergen, L.G. and Morris, N.R. (1983) J. Bacteriol. 156, 155–160.
Morris, N.R. (1976) Genet. Res. 26, 237–254.
O’Connell, M.J., Osmani, A.H., Morris, N.R. and Osmani, S.A. (1992) EMBO J. 11, 2139–2149.
Osmani, A.H., van Peji, N., Mischke, M., O’Connell, M.J. and Osmani, S.A. (1994) J. Cell Sci. 107, 1519–1528.
Lu, K.P. and Means, A.R. (1993) Endo. Rev. 14, 40–58.
Oakley, B.R. and Morris, N.R. (1983) J. Cell Biol. 96, 1155–1158.
Osmani, S.A., Eagle, D.B., Doonan, J.H. and Morris, N.R. (1988) Cell 52, 241–251.
Hanks, S.K., Quinn, A.M. and Hunter, T. (1988) Science 241, 42–52.
O’Connell, M.J., Norbury, C. and Nurse, P. (1994) EMBO J. 13, 4926–4937.
Songyang, Z., Blechner, S., Piwnica-Worms, H. and Cantley, L.C. (1994) Curr. Biol. 4, 973–982.
Draetta, G. (1993) Trends Cell Biol. 3, 287–289.
Rossomando, A.J., Wu, J., Michel, H., Shabanowitz, J., Hunt, D.F., Weber, M.J. and Sturgill, T.W. (1992) Proc. Natl. Acad. Sci. USA 89, 5779–5783.
Anderson, N.G., Maller, J.L., Tonks, N.K. and Sturgill, T.W. (1990) Nature 343, 651–653.
Marshall, C.J. (1994) Curr. Opin. Genet. Dev. 4, 82–89.
Lu, K.P. and Means, A.R. (1995) Adv. Mol. Cell. Biol. (In press).
Lu, K.P., Osmani, S.A., Osmani, A.H. and Means, A.R. (1993) J. Cell Biol. 121, 621–630.
Swenson, K.I., Farell, K.M. and Ruderman, J.V. (1986) Cell 47, 861–870.
Murray, A.W. and Kirschner, M.W. (1989) Science 246, 614–621.
Yew, N., Strobel, M. and Vande Woude, G.F. (1993) Curr. Opin. Genet. Dev. 3, 19–25.
Maller, J.L. (1993) Mol. Cell Biochem. 128, 267–281.
Norbury, C., Blow, J. and Nurse, P. (1991) EMBO J. 10, 3321–3329.
Krek, W. and Nigg, E.A. (1991) EMBO J. 10, 3331–3341.
Pickham, K.M., Meyer, A.N., Li, J. and Donoghue, D.J. (1992) Mol. Cell. Biol. 12, 3192–3203.
Muramatsu, M., Kaibuchi, K. and Arai, K. (1989) Mol. Cell. Biol. 9, 831–836.
Waldmann, R., Hanson, P.I. and Schulman, H. (1990) Biochemistry 29, 1679–1684.
Kuang, J., Zhao, J.Y., Wright, D.A., Saunders, G.F. and Rao, P.N. (1989) Proc. Natl. Acad. Sci. USA 86, 4982–4986.
Gavin, A.C., Vassalli, J.D., Cavadore, J.C. and Schorderet, S.S. (1992) Mol. Reprod. Dev. 33, 287–296.
Sagata, N., Oskarsson, M., Copeland, T., Brumbaugh, J. and Vande, W.G. (1988) Nature 335, 519–525.
Freeman, R.S., Kanki, J.P., Ballantyne, S.M., Pickham, K.M. and Donoghue, D.J. (1990) J. Cell Biol. 111, 533–541.
Mailer, J.L. and Smith, D.S. (1985) Dev. Biol. 109, 150–156.
Gossen, M. and Bujard, H. (1992) Proc. Natl. Acad. Sci. USA 89, 5547–5551.
Eldredge, E.R., Chiao, P.J. and Lu, K.P. (1994) Meth. Enzymol. (In press).
Johnson, R.T. and Rao, P.N. (1970) Nature 226, 717–722.
Kalderon, D., Roberts, B.L., Richardson, W.D. and Smith, A.E. (1984) Cell 39, 499–509.
Matsumura, F. and Yamashiro, S. (1993) Curr. Opin. Cell Biol. 5, 70–76.
Korn, E.D. and Hammer, J.A.I. (1988) Annu Rev Biophys Biophys Chem 17, 23–45.
Titus, M.A. (1993) Curr. Opin. Cell Biol. 5, 77–81.
Fleig, U.N., Gould, K.L. and Nurse, P. (1992) Mol. Cell. Biol. 12, 2295–2301.
Fleig, U.N. and Nurse, P. (1991) Mol. Gen. Gene.t 226, 432–440.
Pines, J. and Hunter, T. (1991) J. Cell Biol. 115, 1–17.
Pines, J. and Hunter, T. (1994) EMBO J. 13, 3772–3781.
Parge, H.E., Arvai, A.S., Murtari, D.J., Reed, S.I. and Tainer, J.A. (1993) Science 262, 387–395.
Kitagawa, M., Okabe, T., Ogino, H., Matsumoto, H., Suzuki-Takahashi, I., Kokubo, T., Higashi, H., Saitoh, S., Taya, Y., Yasuda, H., Ohba, Y., Nishimura, S., Tanaka, N. and Okuyama, A. (1993) Oncogene 8, 2425–2432.
Kitagawa, M., Higashi, H., Takahashi, S.I., Okabe, T., Ogino, H., Taya, Y., Nishimura, S. and Okuyama, A. (1994) Oncogene 9, 2549–2557.
Gale, M.J. and Parsons, M. (1993) Mol. Biochem. Parasitol. 59, 111–121.
Baron, A.B., Davies, C.J., Hutchison, C.A. and Kabak, D.B. (1992) Gene 117, 137–140.
Schweitzer, B. and Philippsen, P. (1992) Mol. Gen. Genet. 234, 164–167.
Letwin, K., Mizzen, L., Motro, B., Ben, D.Y., Bernstein, A. and Pawson, T. (1992) EMBO J. 10, 3521–3531.
Schultz, S.J. and Nigg, E.A. (1993) Cell Growth Differ. 4, 821–830.
Schultz, S.J., Fry, A.M., Sutterlin, C., Reid, T. and Nigg, E.A. (1994) Cell Growth Diff. 5, 625–635.
Levedakou, E.N., He, M., Baptist, E.W., Craven, R.J., Cance, W.G., Welcsh, P.L., Simmons, A., Naylor, S.L., Leach, R.J., Lewis, T.B., Bowcock, A. and Liu, E. T. (1994) Oncogene 9, 1977–1988.
Pines, J. and Hunter, T. (1995) in The Cell Cycle: Frontiers in Molecular Biology (Glover, D.M. and Hutchison, C., eds.) Oxford Univerisity Press, Oxford (in press).
Ye, X.S., Xe, G., Pu, R.T., Fincher, R.R., McGuire, S.L., Osmani, A.H. and Osmani, S.A. (1995) EMBO J. 14, 986–994.
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Lu, K.P., Hunter, T. (1995). The NIMA kinase: A mitotic regulator in Aspergillus nidulans and vertebrate cells. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_15
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DOI: https://doi.org/10.1007/978-1-4615-1809-9_15
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