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Regulation of cell cycle progression following DNA damage

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

DNA damage causes an arrest in cell cycle progression. Checkpoints, which monitor the state of the DNA, exist throughout the cycle and negatively regulate cell cycle transitions when damage is detected. The molecular basis of how these checkpoints are activated, and interact with the cell cycle machinery, is just beginning to be understood. Studies in yeast have identified a number of genes involved in a G2 DNA damage checkpoint, while in mammalian cells a G1 checkpoint has been extensively studied.

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  1. Roche Institute of Molecular Biology, 340 Kingsland Street, Nutley, NJ, 07110, USA

    Carmel Hensey & Jean Gautier

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  1. Carmel Hensey
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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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Hensey, C., Gautier, J. (1995). Regulation of cell cycle progression following DNA damage. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_12

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