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The Role of Growth Factors in Tissue Repair II

Epidermal Growth Factor

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Stanley Cohen described a protein isolated from the submaxillary glands of male mice that caused the premature eyelid opening and tooth eruption in neonatal mice (Cohen, 1962). On the basis of histologically apparent maturation and growth of the epidermis in the treated mouse tissues, Cohen and Elliott (1963) named the active fraction of the gland extract epidermal growth factor (EGF). Gray (1937) described a factor isolated from human urine that inhibited gastric acid secretion and named this factor urogastrone (Gray et al., 1939, 1940). Gregory (1975) reported that the amino acid sequence of urogastrone from human urine was very similar to that of the mouse EGF. Both proteins had cysteines in homologous positions and 27 of the 53 amino acids were identical (Gregory, 1975). Furthermore, the amino acid differences between EGF and urogastrone appeared to be relatively conservative. Because of the apparent functional equivalence of EGF and urogastrone, urogastrone in most instances is called human EGF and is so identified in the following discussion. A number of reviews on EGF have been recently published (King, 1985; Daughaday and Heath, 1984; Gregory, 1985; Stoscheck and King, 1986).

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  1. Amgen, Inc., Thousand Oaks, California, 91320, USA

    Allen R. Banks

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  1. Allen R. Banks
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  1. National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA

    R. A. F. Clark  & P. M. Henson  & 

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© 1988 Springer Science+Business Media New York

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Banks, A.R. (1988). The Role of Growth Factors in Tissue Repair II. In: Clark, R.A.F., Henson, P.M. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1795-5_10

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  • DOI: https://doi.org/10.1007/978-1-4615-1795-5_10

  • Publisher Name: Springer, Boston, MA

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