Autotrophic Acetyl Coenzyme A Biosynthesis in Methanogens
Demonstration of the Ljungdahl-Wood pathway of autotrophic acetyl-CoA biosynthesis in methanogens was a difficult task complicated by the unusual coenzymes of methanogenesis and the lack of detailed knowledge for the acetyl-CoA synthase at the time the work was initiated. Because methanogens provided the first evidence for the widespread distribution of the pathway outside the homoacetogenic clostridia, this work was of special importance. Its eventual success was dependent on the description of the C-1 carriers in the pathway of CO2 reduction to methane and the clostridial acetyl-CoA synthase.
KeywordsLactate Carbon Monoxide Assimilation Pyruvate Folate
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