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Familial Factors and Substance Use Disorders

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Abstract

The most recent large-scale epidemiologic study of psychopathology in the United States indicates that nearly half of the population will experience a major psychiatric illness at some point over their lifetime (Kessler, et al., 1994). Moreover, alcohol abuse and dependence were the most frequently occurring of all disorders, affecting one in every 5 males and one in every 12 females. Drug use disorders, though less common, are highly prevalent and are often associated with alcoholism and other forms of psychopathology. There is also a particularly disturbing trend for substance use among adolescents, with the age of onset of substance dependence steadily decreasing. Substance use disorders (i.e., alcohol and drug use disorders) are often associated with intense suffering, physical and emotional illness, and social and occupational impairment. They have a dramatic impact on the family (particularly among children), important consequences for economic productivity, and high mortality stemming from alcohol- and drug-related accidents, homicide and suicide (e.g., Dawson & Grant, 1993; Lewinsohn, Rohde, & Seeley, 1995). In summary, substance use disorders are a major public health concern that warrants the aggressive pursuit of effective strategies for prevention.

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References

  • Barnes, G. & Weite, J. (1986). Patterns and predictors of alcohol use among 1–12th grade students in New York State. Journal of Studies in Alcohol, 47, 53–62.

    Google Scholar 

  • Baumrind, D. & Moselle, K. A. (1985). A developmental perspective on adolescent drug abuse. Advances in Alcohol and Substance Abuse, 4, 41–67.

    Article  PubMed  Google Scholar 

  • Beidel, D. & Turner, S. (1997). At risk for anxiety: I. Psychopathology in the offspring of anxious parents. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 918–924.

    Article  PubMed  Google Scholar 

  • Biederman, J., Rosenbaum, J. F., Bolduc, E. A., Faraone, S. V., & Hirshfeld, D. R. (1991). A high risk study of young children of parents with panic disorders and agoraphobia with and without comorbid major depression. Psychiatry Research, 37, 333–348.

    Article  PubMed  Google Scholar 

  • Bohman, M. (1978). Some genetic aspects of alcoholism and criminality: A population of adoptees. Archives of General Psychiatry, 35, 269–276.

    Article  PubMed  Google Scholar 

  • Brook, J. S., Lukoff, I. F., & Whiteman, M. (1980). Initiation into adolescent marijuana use. Journal of Genetic Psychology, 137, 133–142.

    Article  PubMed  Google Scholar 

  • Brook, J. S., Whiteman, M., Gordon, A. S., & Cohen, P. (1986a). Dynamics of childhood and adolescent personality traits and adolescent drug use. Developmental Psychobiology, 22, 403–414.

    Google Scholar 

  • Brook, J. S., Whiteman, M., Gordon, A. S., & Cohen, P. (1986b). Some model mechanisms for explaining the impact of maternal and adolescent characteristics on adolescent stage of drug use. Developmental Psychology, 22, 460–467.

    Article  Google Scholar 

  • Brook, J., Whiteman, M., Nomura, C., Gordon, A., & Cohen, P. (1988). Personality, family, and ecological influences on adolescent drug use: A developmental analysis. Journal of Chemical Dependency Treatment, 1, 123–161.

    Article  Google Scholar 

  • Brook, J. S., Brook, D. W., Gordon, A. S., Whiteman, M., & Cohen, P. (1990). A psychosocial etiology of adolescent drug use: A family interactional approach. Genetic, Social and General Psychology Monographs, 116, 111–267.

    Google Scholar 

  • Brook, J., Whiteman, M., & Finch, S. (1993). Role of mutual attachment in drug use: A longitudinal study. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 982–989.

    Article  PubMed  Google Scholar 

  • Brown, S. A., Vic, P. W., Creamer, V. A. (1989). Characteristics of relapse following adolescent substance abuse treatment. Addictive Behaviors, 14, 291–300.

    Article  PubMed  Google Scholar 

  • Cadoret, R. J. (1992). Genetic and environmental factors in initiation of drug use and the transition to abuse. In M. Glantz & R. Pickens (Eds.), Vulnerability to drug abuse (pp. 99–113). Washington, DC: American Psychological Association.

    Chapter  Google Scholar 

  • Cadoret, R. J., Troughton, E., O’ Gorman, T., & Heywood, E. (1986). An adoption study of genetic and environmental factors in drug abuse. Archives of General Psychiatry, 43, 1131–1136.

    Article  PubMed  Google Scholar 

  • Cadoret, R. J., Yates, W. R., Troughton, E., Woodworth, G., & Stewart, M. A. (1995). Adoption study demonstrating two genetic pathways to drug abuse. Archives of General Psychiatry, 52, 42–52.

    Article  PubMed  Google Scholar 

  • Cadoret, R. J., Yates, W. R., Troughton, E., Woodworth, G., & Stewart, M. A. (1996). An adoption study of drug abuse/dependency in females. Comprehensive Psychiatry, 37, 88–94.

    Article  PubMed  Google Scholar 

  • Chassin, L., Rogosch, F., & Barrera, M. (1991). Substance use and symptomatology among adolescent children of alcoholics. Journal of Abnormal Psychology, 100, 449–463.

    Article  PubMed  Google Scholar 

  • Clair, D. & Genest, M. (1987). Variables associated with the adjustment of offspring of alcoholic fathers. Journal of Studies on Alcohol, 48, 345–355.

    PubMed  Google Scholar 

  • Claridge, G., Ross, E., & Hume, W. I. (1978). Sedative drug tolerance in twins. Oxford, England: Pergamon Press.

    Google Scholar 

  • Dawson, D. A. & Grant, B. F. (1993). Gender effects in diagnosing alcohol abuse and dependence. Journal of Clinical Psychology, 49, 298–307.

    Article  PubMed  Google Scholar 

  • Dierker, L. C., Merikangas, K. R., & Szatmari, P. (1999). Influence of parental concordance for psychiatric disorders on psychopathology in offspring. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 280–288.

    Article  PubMed  Google Scholar 

  • Duncan, T. E., Duncan, S. C., Hops, H., & Stoolmiller, M. (1995). An analysis of the relationship between parent and adolescent marijuana use via generalized estimating equation methodology. Multivariate Behavioral Research 30, 317–339.

    Article  Google Scholar 

  • Epstein, N. B., Baldwin, L. M., & Bishop, D. S. (1983). The McMaster family assessment device. Journal of Marital and Family Therapy, 9, 171–180.

    Article  Google Scholar 

  • Farrington, D. P., Gallagher, B., Morley, L., St. Ledger, R. J., & West, D. J. (1988). Are there any successful men from criminogenic backgrounds? Psychiatry 51, 116–130.

    PubMed  Google Scholar 

  • Gabel, S. & Shindledecker, R. (1990). Parental substance abuse and suspected child abuse/maltreatment predict outcome in children’s inpatient treatment. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 919–924.

    Article  PubMed  Google Scholar 

  • Gabel, S. & Shindledecker, R. (1991). Aggressive behavior in youth: Characteristics, outcome, and psychiatric diagnoses. Journal of the Academy of Child and Adolescent Psychiatry, 30, 982–988.

    Article  Google Scholar 

  • Gabel, S. & Shindledecker, R. (1992). Behavior problems in sons and daughters of substance abusing parents. Child Psychiatry & Human Development, 23, 99–115.

    Article  Google Scholar 

  • Geller, B., Cooper, T. B., Sun, K., Zimmerman, B., Frazier, J., Williams, M., & Heath, J. (1998). Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 171–178.

    Article  PubMed  Google Scholar 

  • Gfroerer, J. (1987). Correlation between drug use by teenagers and drug use by older family members. American Journal of Drug and Alcohol Abuse, 13, 95–108.

    Article  PubMed  Google Scholar 

  • Gordon, H. W. (1994). Human neuroscience at National Institute on Drug Abuse: Implications for genetics research. American Journal of Medical Genetics, 54, 300–303.

    Article  PubMed  Google Scholar 

  • Grillon, C., Dierker, L., & Merikangas, K. R. (1998). Fear-potentiated startle in adolescent offspring of parents with anxiety disorders. Biological Psychiatry, 44, 990–997.

    Article  PubMed  Google Scholar 

  • Grove, W., Eckert, E., Heston, L., Bouchard, T., Segal, N., & Lykken, D. (1990). Heritibility of substance abuse and antisocial behavior: A study of monozygotic twins reared apart. Biological Psychiatry, 27, 1293–1304.

    Article  PubMed  Google Scholar 

  • Gurling, H., Grant, S., & Dangl, J. (1985). The genetic and cultural transmission of alcohol use, alcoholism, cigarette smoking and coffee drinking: A review and an example using a log linear cultural transmission model. British Journal of Addiction, 80, 269–279.

    Article  PubMed  Google Scholar 

  • Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992). Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: Implications for substance abuse prevention. Psychological Bulletin, 112, 64–105.

    Article  PubMed  Google Scholar 

  • Heath, A. C., Bucholz, K. K., Madden, P. A., Dinwiddie, S. H., Slutske, W. S., Beirut, L. J., Statham, D. J., Dunne, M. P., Whitfield, J. B., & Martin, N. G. (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: Consistency of findings in women and men. Psychological Medicine, 27, 1381–1396.

    Article  PubMed  Google Scholar 

  • Hill, S. H., Cloninger, C. R., & Ayre, F. R. (1977). Independent familial transmission of alcoholism and opiate abuse. Alcoholism: Clinical and Experimental Research, 1, 335–342.

    Article  Google Scholar 

  • Hill, S. Y., Steinhauer, S. R., & Zubin, J. (1992). Cardiac responsivity in individuals at high risk for alcoholism. Journal of Studies on Alcohol, 53, 378–388.

    PubMed  Google Scholar 

  • Holden, M. G., Brown, S. A., & Mott, M. A. (1988). Social support network of adolescents: Relation to family alcohol abuse. American Journal of Drug and Alcohol Abuse, 14, 487–498.

    Article  PubMed  Google Scholar 

  • Jang, K. L., Livesley, W. J., & Vernon, P. A. (1995). Alcohol and drug problems: A multivariate behavioral genetic analysis of co-morbidity. Addiction, 90, 1213–1221.

    Article  PubMed  Google Scholar 

  • Johnson, S., Leonard, K. E., & Jacob, T. (1989). Drinking, drinking styles and drug use in children of alcoholics, depressives, and controls. Journal of Studies on Alcohol, 50, 427–431.

    PubMed  Google Scholar 

  • Kandel, D. B. (1990). Parenting styles, drug use, and children’s adjustment in families of young adults. Journal of Marriage and the Family, 52, 183–196.

    Article  Google Scholar 

  • Kandel, D. B. & Andrews, K. (1987). Processes of adolescent socialization by parents and peers. International Journal of the Addictions, 22, 319–42.

    PubMed  Google Scholar 

  • Kaplan, H. B. (Ed.). (1995). Drugs, crime and other deviant adaptations: Longitudinal studies. New York: Plenum.

    Google Scholar 

  • Kendler, K. & Prescott, C. (1998). Cannabis use, abuse and dependence in a population-based sample of female twins. American Journal of Psychiatry, 155, 1016–1022.

    PubMed  Google Scholar 

  • Kendler, K., Neale, M., Kessler, R., Heath, A., & Eaves, L. (1992). A population-based twin study of major depression in women: The impact of varying definitions of illness. Archives of General Psychiatry, 49, 257–266.

    Article  PubMed  Google Scholar 

  • Kendler, K., Neale, M., Kessler, R., Heath, A., & Eaves, L. (1993). Major depression and phobias: The genetic and environmental sources of comorbidity. Psychological Medicine, 23, 361–371.

    Article  PubMed  Google Scholar 

  • Kendler, K. S., Eaves, L. J., Walters, E. E., Neale, M. C., Heath, A. C., & Kessler, R. C. (1996). The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Archives of General Psychiatry, 53, 391–399.

    Article  PubMed  Google Scholar 

  • Kessler, R. & Price, R. (1993). Primary prevention of secondary disorders: A proposal and agenda. American Journal of Community Psychology, 21, 607–633.

    Article  PubMed  Google Scholar 

  • Kessler, R., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshleman, S., Wittchen, H. U., & Kendler, S. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Survey. Archives of General Psychiatry, 51, 8–19.

    Article  PubMed  Google Scholar 

  • King, M. C., Lee, G. M., Spinner, N. B., Thomson, G., & Wrensch, M. R. (1984). Genetic epidemiology. Annual Review of Public Health, 5, 1–52.

    Article  PubMed  Google Scholar 

  • Kuller, L. H. (1979). The role of population genetics in the study of the epidemiology of cardiovascular risk factors. In D. C. Rao, R. Elston, L. H. Kuller, M. Feinleib, C. Carter, & R. Havlick (Eds.), Genetic analysis of common disease: Application to predictive factors in coronary disease (pp. 489–495). New York: Alan R. Liss.

    Google Scholar 

  • Kumpfer, K., Molgaard, V., & Spoth, R. (1996). The Strengthening Families Program for the prevention of delinquency and drug use. In R. DeV. Peters & R. J. McMahon (Eds.), Preventing childhood disorders, substance abuse, and delinquency (pp. 241–267). Thousand Oaks, CA: Sage Publications.

    Google Scholar 

  • Lewinsohn, P., Rohde, P., & Seeley, J. (1995). Adolescent psychopathology: III. The clinical consequences of comorbidity. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 510–519.

    Article  PubMed  Google Scholar 

  • Lipman, E. L., Offord, D. R., & Boyle, M. H. (1993). Follow-up of psychiatric and educational morbidity among adopted children. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 1007–1012.

    Article  PubMed  Google Scholar 

  • Luthar, S. S., Anton, S. F., Merikangas, K. R., & Rounsaville, B. J. (1992). Vulnerability to substance abuse and psychopathology among siblings of opioid abusers. The Journal of Nervous and Mental Disorders, 180, 153–161.

    Article  Google Scholar 

  • Lyons, M. J., Toomey, R., Meyer, J. M., Green, A. I., Eisen, S. A., Goldberg, J., True, W. R., & Tsuang, M. T. (1997). How do genes influence marijuana use? The role of subjective effects. Addiction, 92, 409–417.

    Article  PubMed  Google Scholar 

  • MacKinnon, A., Henderson, A. S., & Duncan-Jones, P. (1989). The Parental Bonding Instrument (PBI): An epidemiological study in a general population sample. Psychological Medicine, 19, 1023–1034.

    Article  PubMed  Google Scholar 

  • MacMahon, B. (1968). Gene environment interaction in human disease. Journal of Psychiatric Research, 6, 393–402.

    Article  Google Scholar 

  • Maier, W. & Merikangas, K. R. (1992). Co-transmission and comorbidity of affective disorders, anxiety disorders and alcoholism in families. Berlin: Springer-Verlag.

    Google Scholar 

  • Maier, W., Buller, R., & Hallmayer, J. (1988). Comorbidity of panic disorder and major depression: Results from a family study. In I. Hand & H. U. Wittchen (Eds.), Panic and phobias: Treatments and variables affecting course and outcome (pp. 180–185). Berlin: Springer-Verlag.

    Google Scholar 

  • Marley, R., Witkin, J., & Goldberg, S. (1991). Genetic factors influence changes in sensitivity to the convulsant properties of cocaine following chronic treatment. Brain Research, 542, 1–7.

    Article  PubMed  Google Scholar 

  • Martin, C. S., Earleywine, M., Blackson, T. C., Vanyukov, M. M., Moss, H. B., & Tarter, R. E. (1994). Aggression, inattention, hyperactivity, and impulsivity in boys at high and low risk for substance abuse. Journal of Abnormal Child Psychology, 22, 177–203.

    Article  PubMed  Google Scholar 

  • Mausner, J. S. & Kramer, S. (1984). Epidemiology: An introductory text (2nd ed.). Philadelphia: W.B. Saunders.

    Google Scholar 

  • McCarthy, W. J. & Anglin, M. D. (1990). Narcotics addicts: Effect of family and parental risk factors on timing of emancipation, drug use onset, pre-addiction incarcerations, and educational achievement. Journal of Drug Issues, 20, 99–123.

    Google Scholar 

  • McGue, M. (1994). Genes, environment, and the etiology of alcoholism. Development of alcohol problems: Exploring the biopsychosocial matrix, 26 (Serial No. 94–3495), 1–40.

    Google Scholar 

  • Meller, W., Rinehart, R., Cadoret, R., & Troughton, E. (1988). Specific familial transmission in substance abuse. The International Journal of the Addictions, 23, 1029–1039.

    PubMed  Google Scholar 

  • Merikangas, K. R. (1990). Comorbidity for anxiety and depression: Review of family and genetic studies. In J. D. Maser & C. R. Cloninger (Eds.), Comorbidity of mood and anxiety disorders (pp. 331–348). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Merikangas, K. R. & Kupfer, D. J. (1995). Mood disorders: Genetic aspects. Baltimore, M.D.: Williams & Wilkens.

    Google Scholar 

  • Merikangas, K. R., Leckman, J. F., Prusoff, B. A., Pauls, D. L., & Weissman, M. M. (1985). Familial transmission of depression and alcoholism. Archives of General Psychiatry, 42, 367–372.

    Article  PubMed  Google Scholar 

  • Merikangas, K. R., Rounsaville, B. J., & Prusoff, B. A. (1992). Familial factors in vulnerability to substance abuse. Washington, DC: American Psychological Association.

    Google Scholar 

  • Merikangas, K. R., Risch, N. J., & Weissman, M. M. (1994). Comorbidity and co-transmission of alcoholism, anxiety and depression. Psychological Medicine, 24, 69–80.

    Article  PubMed  Google Scholar 

  • Merikangas, K. R., Dierker, L. C., & Szatmari, P. (1998a). Psychopathology among offspring of parents with substance abuse and/or anxiety: A high risk study. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 711–720.

    Google Scholar 

  • Merikangas, K. R., Stevens, D. E., Fenton, B., O’Malley, S., Woods, S. W., Stolar, M., & Risch, N. (1998b). Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychological Medicine, 28, 773–788.

    Article  PubMed  Google Scholar 

  • Merikangas, K. R., Stolar, M., Stevens, D. E., Goulet, J., Preisig, M., Fenton, B., O’Malley, S., & Rounsaville, B.J. (1998c). Familial transmission of substance use disorders. Archives of General Psychiatry, 55, 973–979.

    Article  PubMed  Google Scholar 

  • Miller, I. W., Kabacoff, R. I., Keitner, G. I., Epstein, N. B., & Bishop, D. S. (1986). Family functioning in the families of psychiatric patients. Comprehensive Psychiatry, 27, 302–312.

    Article  PubMed  Google Scholar 

  • Mirin, S. M., Weiss, R. D., & Michael, J. (1988). Psychopathology in substance abusers: Diagnosis and treatment. American Journal of Drug and Alcohol Abuse, 14, 139–157.

    Article  PubMed  Google Scholar 

  • Mirin, S. M., Weiss, R. D., Griffin, M. L., & Michael, J. L. (1991). Psychopathology in drug abusers and their families. Comprehensive Psychiatry, 32, 36–51.

    Article  PubMed  Google Scholar 

  • Molina, B. S. G., Chassin, L., & Curran, P. J. (1994). A comparison of mechanisms underlying substance use for early adolescent children of alcoholics and controls. Journal of Studies on Alcohol, 55, 269–275.

    PubMed  Google Scholar 

  • Morton, N. (1982). Outline of genetic epidemiology. Basel: Karger.

    Google Scholar 

  • Moss, H. B., Majumder, P. P., & Vanyukov, M. (1994). Familial resemblance for psychoactive substance use disorders: Behavioral profile of high risk boys. Addictive Behaviors, 19, 199–208.

    Article  PubMed  Google Scholar 

  • Moss, H. B., Mezzich, A., Yao, J. K., Gavaler, J., & Martin, C. S. (1995). Aggression among sons of substance-abusing fathers: Association with psychiatric disorder in the father and son, paternal personality, pubertal development, and socioeconomic status. American Journal of Drug and Alcohol Abuse, 21, 195–208.

    Article  PubMed  Google Scholar 

  • Olson, D. H., Spenkle, D. H. J., & Russell, C. S. (1979). Complex model of marital and family systems. 1. Cohesion and adaptability dimensions, family types and clinical applications. Family Process, 18, 3–78.

    Article  PubMed  Google Scholar 

  • Olson, D. H., Portner, J., & Bell, R. (1985a). Family Adaptability and Cohesion Evaluation Scales (FACES II). Family Social Science. Unpublished manual. St. Paul: University of Minnesota.

    Google Scholar 

  • Olson, D. H., Portner, J., & Lavee, Y. (1985b). FACES III. Family Social Science. St. Paul: University of Minnesota.

    Google Scholar 

  • Orvaschel, H., Puig-Antich, J., Chambers, W., Tabrizi, M. A., & Johnson, R. (1982). Retrospective assessment of prepubertal major depression with the Kiddie-SADS-E. Journal of the American Academy of Child and Adolescent Psychiatry, 21, 392–397.

    Article  Google Scholar 

  • Parker, G., Tupling, H., & Brown, L. B. (1979). A parental bonding instrument. British Journal of Medical Psychology, 52, 1–10.

    Article  Google Scholar 

  • Patterson, G. R. (1986). Performance models for antisocial boys. American Psychologist, 41, 432–444.

    Article  PubMed  Google Scholar 

  • Patterson, G. R., Chamberlain, P., & Reid, J. B. (1982). A comparative evaluation of parent training programs. Behavior Therapy, 13, 638–650.

    Article  Google Scholar 

  • Pedersen, N. (1981). Twin similarity for usage of common drugs. New York: Alan R. Liss.

    Google Scholar 

  • Peterson, J. L. & Zill, N. (1986). Marital disruption, parent-child relationships, and behavior problems in children. Journal of Marriage and the Family, 48, 295–307.

    Article  Google Scholar 

  • Pickens, R., Svikis, D., McGue, M., Lykken, D., Heston, L., & Clayton, P. (1991). Heterogeneity in the inheritance of alcoholism: A study of male and female twins. Archives of General Psychology, 48, 19–28.

    Article  Google Scholar 

  • Plantes, M. M., Prusoff, B. A., Brennen, J., & Parker, G. (1988). Parental representations of depressed outpatients from a U.S.A. sample. Journal of Affective Disorders, 15, 149–155.

    Article  PubMed  Google Scholar 

  • Reich, W., Earls, F., Frankel, O., & Shayka, J. J. (1993). Psychopathology in children of alcoholics. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 955–1002.

    Article  Google Scholar 

  • Rhodes, J. E. & Jason, L. A. (1990). A social stress model of substance abuse. Journal of Consulting and Clinical Psychology, 58, 395–401.

    Article  PubMed  Google Scholar 

  • Robins, L. N. (1980). The natural history of drug abuse. Acta Psychiatrica Scandinavica, Supplementum 284, 7–20.

    Article  Google Scholar 

  • Robins, L. (1992). The future of psychiatric epidemiology. International Journal of Methods in Psychiatric Research, 2, 1–3.

    Google Scholar 

  • Roosa, M. W., Beals, J., Sandler, I. N., & Pillow, D. R. (1990). The role of risk and protective factors in predicting symptomatology in adolescent self-identified children of alcoholic parents. American Journal of Community Psychology, 18, 725–741.

    Article  PubMed  Google Scholar 

  • Rounsaville, B. J., Tierney, T., Crits-Christoph, K., Weissman, M. M., & Kleber, H. D. (1982). Predictors of treatment outcome in opiate addicts: Evidence for the multidimensionality of addicts’ problems. Comprehensive Psychiatry, 23, 462–478.

    Article  PubMed  Google Scholar 

  • Rounsaville, B. J., Kosten, T. R., Weissman, M. M., Prusoff, B., Pauls, D., Anton, S. F., Merikangas, K. (1991). Psychiatric disorders in the relatives of probands with opiate addiction. Archives of General Psychiatry, 48, 33–42.

    Article  PubMed  Google Scholar 

  • Sher, K. J., Walitzer, K. S., Wood, P. K., & Brent, E. E. (1991). Characteristics of children of alcoholics: Putative risk factors, substance use and abuse, and psychopathology. Journal of Abnormal Psychology, 100, 427–448.

    Article  PubMed  Google Scholar 

  • Smart, L. S., Chibucos, T. R., & Didier, L. A. (1990). Adolescent substance use and perceived family functioning. Journal of Family Issues, 11, 208–227.

    Article  Google Scholar 

  • Susser, M. (1985). Separating heredity and environment. American Journal of Preventive Medicine 1, 5–23.

    PubMed  Google Scholar 

  • Sylvester, C. E., Hyde, T. S., & Reichler, R. J. (1987). Clinical psychopathology among children of adults with panic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 668–675.

    Article  PubMed  Google Scholar 

  • Sylvester, C., Hyde, T., & Reichler, R. (1988). Clinical psychopathology among children of adults with panic disorder. In D. Dunner, E. Gershon, & J. Barrett (Eds.), Relatives at risk for mental disorder (pp. 87–102). New York: Raven Press.

    Google Scholar 

  • Tsuang, M. T., Lyons, M. J., Eisen, S. A., Goldberg, J., True, W., Lin, N., Meyer, J. M., Toomey, R., Faraone, S. V., & Eaves, L. (1996). Genetic influences on DSM-III-R drug abuse and dependence: A study of 3372 twin pairs. American Journal of Medical Genetics 67, 473–477.

    Article  PubMed  Google Scholar 

  • Tsuang, M. T., Lyons, M. J., Meyer, J. M., Doyle, T., Eisen, S. A., Goldberg, J., True, W., Lin, N., Toomey, R., & Eaves, L. (1998). Co-occurence of abuse of different drug in men: The role of drug-specific and shared vulnerabilities. Archives of General Psychiatry, 55, 967–972.

    Article  PubMed  Google Scholar 

  • Turner, S. M., & Beidel, D. C. (1988). Some further comments on the measurement of social phobia. Behaviour Research and Therapy, 26, 411–413.

    Article  PubMed  Google Scholar 

  • Turner, S. M., Beidel, D. C., & Costello, A. (1987). Psychopathology in the offspring of anxiety disorders patients. Journal of Consulting and Clinical Psychology, 55, 229–235.

    Article  PubMed  Google Scholar 

  • Wahlberg, K. E., Wynne, L. C., Oja, H., Keskitalo, P., Pykalainen, L., Lahti, I., Moring, J., Naarala, M., Sorri, A., Seitamaa, M., Laksy, K., Kolassa, J., & Tienari, P. (1997). Gene-environment interaction in vulnerability to schizophrenia: Findings from the Finnish Adoptive Family Study of Schizophrenia. American Journal of Psychiatry, 154, 355–362.

    PubMed  Google Scholar 

  • Warner, L., Kessler, R., Hughes, M., Anthony, J., & Nelson, C. (1995a). Prevalence and correlates of drug use and dependence in the United States. Archives of General Psychiatry, 52, 219–229.

    Article  PubMed  Google Scholar 

  • Warner, V., Mufson, L., & Weissman, M. (1995b). Offspring at high risk for depression and anxiety: Mechanisms of psychiatric disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 786–797.

    Article  PubMed  Google Scholar 

  • West, M. O. & Prinz, R. J. (1987). Parental alcoholism and childhood psychopathology. Psychological Bulletin, 102, 204–218.

    Article  PubMed  Google Scholar 

  • Wilens, T., Biederman, J., Kiely, K., Bredin, E., & Spencer, T. (1994). Pilot study of behavioral and emotional disturbances in the high-risk children of parents with opioid dependence. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 779–785.

    Article  Google Scholar 

  • Zimmerman, M., Coryell, W., & Pfohl, B. (1986). Validity of familial subtypes of primary unipolar depression. Archives of General Psychiatry, 43, 1090–1096.

    Article  PubMed  Google Scholar 

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© 2002 Springer Science+Business Media New York

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Merikangas, K.R. (2002). Familial Factors and Substance Use Disorders. In: McMahon, R.J., Peters, R.D. (eds) The Effects of Parental Dysfunction on Children. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1739-9_2

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  • DOI: https://doi.org/10.1007/978-1-4615-1739-9_2

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