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Brain Injury pp 57–70Cite as

Preconditioning

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Part of the book series: Molecular and Cellular Biology of Critical Care Medicine ((MCCM,volume 2))

Abstract

Patients with critical illnesses often have preexisting medical conditions that may or may not contribute to the acute process. These conditions also may serve to mitigate or exacerbate the sequelae of the acute event and one process that may attenuate the damage of an acute injury is preconditioning. Preconditioning is the phenomenon whereby a non-lethal stimulus sets in motion a cascade of biochemical events that renders cells, tissues or the whole organism tolerant to a future more lethal stimulus. This process was initially studied using ischemia as a primary stimulus within the myocardium, but now has been extensively studied in the brain as well.

“What does not kill me, makes me stronger”, Johann Wolfgang van Goethe, German philosopher, 1749–1842

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Author information

Authors and Affiliations

  1. Children’s National Medical Center, Washington, DC, USA

    Michael J. Bell & John M. Hallenbeck

  2. Stroke Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA

    Michael J. Bell & John M. Hallenbeck

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  1. Michael J. Bell
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  2. John M. Hallenbeck
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Editors and Affiliations

  1. Pediatric Critical Care Medicine, Children’s Hospital of Pittsburgh, Pittsburgh, PA, 15213, USA

    Robert S. B. Clark M.D.

  2. Safar Center for Resuscitation Research, Pittsburgh, PA, USA

    Patrick Kochanek M.D.

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Bell, M.J., Hallenbeck, J.M. (2001). Preconditioning. In: Clark, R.S.B., Kochanek, P. (eds) Brain Injury. Molecular and Cellular Biology of Critical Care Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1721-4_3

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  • DOI: https://doi.org/10.1007/978-1-4615-1721-4_3

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