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Myxoma Virus Expresses a TNF Receptor Homolog with two Distinct Functions

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Molecular Evolution of Viruses — Past and Present

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Abstract

Myxoma virus, a member of the poxvirus family of DNA viruses, encodes many virulence factors to combat and evade the host immune responses. Among the virus-encoded immuno-modulators is M-T2, a tumor necrosis factor receptor (TNF-R) homologue. M-T2 is secreted as monomeric and dimeric species that bind and inhibit rabbit TNF in a species-specific manner. Deletion analysis indicates that the anti-TNF function is mediated by the first three of four cysteine rich domains (CRDs) of M-T2. In addition, the intracellular form of M-T2 has the ability to block virus-induced apoptosis in lymphocytes, and the first two CRDs appear to be sufficient for this function. Although the mechanisms for the anti-TNF and anti-apoptotic functions of M-T2 are not yet fully defined, we postulate that these dual activities of M-T2 are mediated through different functional motifs and abrogate distinct cellular responses to virus infection.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Western Ontario and The John P. Robarts Research Institute, London, Ontario, Canada, N6G 2V4

    Xiaoming Xu, Piers Nash & Grant McFadden

  2. Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7

    Piers Nash

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  1. Xiaoming Xu
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  2. Piers Nash
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  3. Grant McFadden
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Editors and Affiliations

  1. Department of Molecular Virology, The Hebrew University of Jerusalem, Jerusalem, Israel

    Yechiel Becker

  2. Institute of Medical Virology, Ruprecht-Karls University, Heidelberg, Germany

    Gholamreza Darai

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Xu, X., Nash, P., McFadden, G. (2000). Myxoma Virus Expresses a TNF Receptor Homolog with two Distinct Functions. In: Becker, Y., Darai, G. (eds) Molecular Evolution of Viruses — Past and Present. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1707-8_9

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  • DOI: https://doi.org/10.1007/978-1-4615-1707-8_9

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