Gene Therapy for HIV and AIDS-Related Opportunistic Infections
Gene therapy was initially conceptualised as gene replacement treatment for genetic diseases, particularly diseases that are inherited in an autosomal recessive fashion and carry a significant morbidity, such as Cystic Fibrosis. However, as the field has expanded, it has taken advantage of the increasing knowledge base that there are genetic components to acquired disorders such as cancer, HIV infection and other infectious diseases. For example, those individuals that lack expression of the HIV chemokine co-receptor are resistant to HIV infection and progression of the disease to AIDS. Moreover, knowing the operative host defence mechanisms against certain pathogens may allow one to exploit these pathways for therapeutic purposes using gene transfer technology. This article will focus on the evolving strategies to use gene-based therapies in HIV infection, TB, and Pneumocystis carinii pneumonia.
KeywordsToxicity Pneumonia Interferon Pseudomonas Rosen
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