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Gene Therapy Strategies to Augment Contractile Function in Heart Failure

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Abstract

Congestive heart failure (CHF) represents a leading cause for hospitalization in the United States and other developed nations. Despite vast improvements in the management of coronary artery disease over the past decades, an effective treatment of CHF remains elusive. Heart failure itself represents a final common endpoint for several disease entities, including hypertension, coronary artery disease, and cardiomyopathy. Several biochemical features, however, remain common to the failing myocardium. These include, but are not limited to, adrenergic desensitization and changes in calcium homeostasis. These molecular alterations may, in turn, offer potential therapeutic targets for genetic manipulation. In this chapter, we will review the changes in adrenergic signaling and calcium handling that occur in CHF. We will then examine the specific approaches to augment biochemical and physiologic function that address these alterations. Finally, we will review cardiac gene transfer vectors as well as technical approaches to myocardial gene delivery.

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Authors and Affiliations

  1. Department of Surgery, Duke University Medical Center, Durham, NC, USA

    Michael J. Davidson M.D. & Walter J. Koch Ph.D.

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  1. Michael J. Davidson M.D.
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Editors and Affiliations

  1. Pulmonary and Critical Care Medicine Evanston Northwestern Healthcare, USA

    Phillip Factor D.O., F.C.C.P.

  2. Northwestern University Medical School, USA

    Phillip Factor D.O., F.C.C.P.

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Davidson, M.J., Koch, W.J. (2001). Gene Therapy Strategies to Augment Contractile Function in Heart Failure. In: Factor, P. (eds) Gene Therapy for Acute and Acquired Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1667-5_11

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  • DOI: https://doi.org/10.1007/978-1-4615-1667-5_11

  • Publisher Name: Springer, Boston, MA

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