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Chemoprevention of Colon Cancer

  • Chapter
Cancer Chemoprevention

Part of the book series: Cancer Treatment and Research ((CTAR,volume 106))

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Abstract

Adenocarcinoma of the large bowel presents a major public health problem. It affects about 1 person in 20 in the United States and Western countries [1]. It is the second most common cause of cancer death in American males, and the third most common cause in American females. When diagnosed and treated in its early stages, it is a highly curable disease. However, only half of all patients who present with colorectal cancer are cured by primary resection [2]. Primary prevention through the identification and eradication of risk factors responsible for the development of colorectal cancer is an area of active research throughout the world. Both environmental and genetic factors have been causally related to the development of colorectal cancer. Secondary prevention, by identifying premalignant lesions through screening techniques such as endoscopy, fecal occult blood testing, air-contrast barium enema, and CT colonography may potentially lead to a dramatic reduction in mortality. As a result of our improved understanding of the pathogenesis of colorectal cancer, the role of chemoprevention, either as primary or secondary prevention, and the targets for prevention, have been more readily defined.

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Authors
  1. Mary Mulcahy M.D.
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  2. Al Benson III M.D.
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Editor information

Editors and Affiliations

  1. Robert H. Lurie Comprehensive Cancer Center, Northwestern University School of Medicine, USA

    Raymond C. Bergan MD (Director, Experimental Therapeutics) (Director, Experimental Therapeutics)

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© 2001 Springer Science+Business Media New York

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Mulcahy, M., Benson, A. (2001). Chemoprevention of Colon Cancer. In: Bergan, R.C. (eds) Cancer Chemoprevention. Cancer Treatment and Research, vol 106. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1657-6_7

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  • DOI: https://doi.org/10.1007/978-1-4615-1657-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5663-9

  • Online ISBN: 978-1-4615-1657-6

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