Chemoprevention in Prostate Cancer

  • Chadi Nabhan
  • Raymond Bergan
Part of the Cancer Treatment and Research book series (CTAR, volume 106)


Prostate cancer is the most frequently diagnosed malignancy in American men. It will be diagnosed in an estimated 180,400 Americans in 2000, causing death in approximately 31,900 (1). World wide, these numbers are much higher (1). Even in those who do not die from disease, treatment is associated with significant morbidity (2). There are a number of features particular to prostate cancer which make it an ideal disease model for the development and implementation of effective chemopreventive approaches. It is a disease characterized by a long latency period. Stages within this latency period are relatively well characterized, and can be detected clinically. In addition to the high incidence of prostate cancer in Western countries, its clinical course is very consistent. Finally, data from epidemiologic studies is consistent with the notion that pharmacologic intervention can in fact favorably affect the incidence of prostate cancer. The ability to effectively prevent the occurrence and/or the progression of prostate cancer would have a significant clinical impact. This chapter first provides a review of chemoprevention strategies, and then goes on to discuss relevant biochemistry, epidemiology and specific chemopreventive agents, and their associated mechanisms of action, as they relate to prostate cancer.


Prostate Cancer Epidermal Growth Factor Receptor Prostate Specific Antigen Benign Prostatic Hyperplasia Prostate Cancer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Chadi Nabhan
  • Raymond Bergan

There are no affiliations available

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