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Detection of Apoptosis for the Noninvasive Diagnosis of Cardiac Allograft Rejection

  • Francis G. Blankenberg
  • Jagat Narula
  • Johnathan F. Tait
  • Robert C. Robbins
  • H. William Strauss

Abstract

An important feature of transplant rejection is the immune mediated death of graft myocytes and host mononuclear cells invading the graft. In this instance, a major cause of cell death is apoptosis as mentioned in previous chapters. This stereo-typed form of cell death is associated with the expression of phosphatidylserine (PS) on the surface of the apoptotic cell (most likely as a signaling mechanism to adjacent cells and phagocytes). A physiologic protein, annexin V, binds with nanomolar affinity to cell membrane bound PS, and likely plays an important role in the cell-cell signaling and local inhibition of apoptotic cell death. We describe the animal model work and the initial clinical imaging potential of radiolabeled annexin V imaging.

Keywords

Annexin Versus Acute Rejection Transplant Rejection Cardiac Allograft Cardiac Allograft Rejection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Francis G. Blankenberg
    • 1
  • Jagat Narula
    • 1
  • Johnathan F. Tait
    • 1
  • Robert C. Robbins
    • 1
  • H. William Strauss
    • 1
  1. 1.Stanford University Medical CenterStanfordUSA

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