Immunopathogenesis of HIV and HTLV-1 Infection: Mechanisms for Lymphomagenesis

  • Alok A. Khorana
  • Joseph D. Rosenblatt
  • Faith M. Young
Part of the Cancer Treatment and Research book series (CTAR, volume 104)


The immune system in humans is a complex and tightly regulated system that integrates the activity of many cell lineages, including lymphocytes. Lymphoid-lineage cells (B- and T-lymphocytes) are specialized subsets of cells capable of rapid expansion and wide dissemination to effect recognition and elimination of environmental pathogens (adaptive immunity) or abnormal cells (immune surveillance). The patterns of circulation, proliferative potential, and the exquisite sensitivity to regulatory signals that are prominent characteristics of normal lymphocytes can also contribute to significant morbidity in the individual who develops an aggressive B-lymphoid malignancy.


Human Immunodeficiency Virus Type Germinal Center Latent Membrane Protein Serum Response Factor Primary Effusion Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Alok A. Khorana
    • 1
  • Joseph D. Rosenblatt
    • 1
  • Faith M. Young
    • 1
  1. 1.Cancer Center and Hematology-Oncology UnitUniversity of Rochester Medical CenterRochester

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