Hematopoiesis in HIV Infection: Use of Colony Stimulating Factors and Cytokines

  • Elaine Sloand
Part of the Cancer Treatment and Research book series (CTAR, volume 104)


HIV infection is frequently accompanied by defects in hematopoiesis, particularly in those who have advanced HIV disease. There are multiple potential causes, including disorders that occur secondary to the HIV infection (e.g., infection, bone marrow infiltration by lymphoma), its treatment (e.g., sulfa, zidovudine), or primary infection of hematopoietic cells or stromal cells. Even those HIV-infected patients who have apparently normal hematopoiesis and normal blood counts are more prone to the myelosuppressive effects of cytotoxic therapy or other hematosuppressive medications. This chapter will discuss the potential causes of abnormal hematopoiesis that occurs in HIV infection, and the role of colony stimulating factors (CSFs) and cytokines in their management.


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Human Immunodeficiency Virus Infection Bone Marrow Infiltration Oral Ganciclovir 
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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Elaine Sloand
    • 1
  1. 1.National Institute of HealthUSA

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