Biology of Anogenital Neoplasia

  • Anna S. Kadish
Part of the Cancer Treatment and Research book series (CTAR, volume 104)


Cancers of the anogenital area, including uterine cervical carcinoma, vulvar and vaginal, penile, and anal carcinomas occur with increased frequency in HIV-infected individuals.123456Human papillomavirus (HPV) infection has been implicated as an etiologic agent, producing lesions ranging from genital warts (condylomata accuminata), to squamous intraepithelial lesions (SIL) that may involve the cervix (cervical intraepithelial lesions - CIN) or anus (anal intraepithelial lesions - AIL), and finally to invasive squamous cell carcinoma of the cervix, anus, or other genital organs. In patients with HIV infection, there is an increased incidence of CIN in women and AIL in both men and women (Figure1, Figure2, Figure3, Figure4). Intraepithelial lesions and carcinomas of the skin, including the perianal region, vulva, and penis have also been associated with HPV infection. In the non-immunosuppressed individuals, intraepithelial lesions often undergo spontaneous regression. In the setting of HIV infection, however, most lesions persist and some progress to invasive carcinoma.


Cervical Cancer Cervical Intraepithelial Neoplasia Vulvar Intraepithelial Neoplasia Tumor Rejection Antigen Anogenital Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Anna S. Kadish
    • 1
  1. 1.Albert Einstein College of MedicineAlbert Einstein Comphrensive Cancer CenterAmerica

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