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Evolving Concepts in Sepsis and Septic Shock pp 129–143Cite as

Anti-Inflammatory Therapy in Sepsis

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Part of the book series: Perspectives on Critical Care Infectious Diseases ((CCID,volume 2))

Abstract

Despite advances in supportive care and medical technology, the mortality rate from sepsis remains high (35–50%) (1). It is the most common cause of death in non-cardiac intensive care units, and the incidence appears to be rising (2). Over the last 20 years, prevailing thought has attributed much of the morbidity and mortality of sepsis to an overexuberant host inflammatory response to bacteria or bacterial products. In preclinical studies, agents designed to limit this host pro-inflammatory response showed promising effects, prompting numerous clinical trials.

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Authors and Affiliations

  1. Johns Hopkins University and the National Institutes of Health, USA

    Jonathan Sevransky M.D. & Charles Natanson M.D.

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  1. Jonathan Sevransky M.D.
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  2. Charles Natanson M.D.
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Editors and Affiliations

  1. Critical Care Medicine Department, Warren Grant Magnuson Clinical Center National Institutes of Health, 10 Center Drive Building 10, Room 7D43, Bethesda, MD, 20892, USA

    Peter Q. Eichacker M.D.

  2. Division of Medical Intensive Care, University Hospital of Geneva, CH-1211, Geneva 14, Switzerland

    Jérôme Pugin M.D.

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Sevransky, J., Natanson, C. (2001). Anti-Inflammatory Therapy in Sepsis. In: Eichacker, P.Q., Pugin, J. (eds) Evolving Concepts in Sepsis and Septic Shock. Perspectives on Critical Care Infectious Diseases, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1581-4_9

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  • DOI: https://doi.org/10.1007/978-1-4615-1581-4_9

  • Publisher Name: Springer, Boston, MA

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