Impact of Genomic Variations on Inflammatory Processes and Sepsis

  • Frank Stüber
Part of the Perspectives on Critical Care Infectious Diseases book series (CCID, volume 2)


The immune response to injury involves a complex pattern of primary, secondary and tertiary humoral and cellular responses. Genetic variability in the expression of the mediators comprising these responses constitutes the genetic background which may potentially influence the course of inflammation in each individual. Differences in this background may in part explain the highly variable clinical courses noted among septic patients. Comparable doses of infecting microbes may induce a wide range of severity of illness due in part to genetic variability.


Septic Shock Severe Sepsis Cerebral Malaria Single Base Change Tumor Necrosis Factor Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Frank Stüber
    • 1
  1. 1.Department of Anesthesiology and Critical Care MedicineUniversity of BonnBonnGermany

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