Abstract
Growth hormone (GH) secretion is under the control of two hypothalamic peptides (1). GH-releasing hormone (GHRH), a peptide of 44 amino acids, which stimulates GH release and somatostatin, which exists both as 14 and 28 amino acid peptides, which inhibits GH secretion. GH secretion is regulated by negative feed-back and neural control mechanisms. Both GH and IGF-1 inhibit GH secretion after intraventricular injection by promoting hypothalamic somatostain release. Presumably, physiological concentration of GH and IGF1 reaching the hypothalamus in the bloodstream act in the same way (increase in somatostatin tone). In addition, IGF-1 may act directly on the pituitary to inhibit GHRHstimulated secretion of GH. GH secretion can be augmented or inhibited by a number of neurogenic, metabolic, and hormonal influences (Figure 1). In the adult, the diurnal pattern of GH secretion has been characterized by obtaining blood samples every 20 or 30 minutes throughout a 24-hour period under non stressful conditions. During most of the day, plasma GH levels of normal adults are less than 5 ng/mL, with one or two sharp spikes three to four hours after meals. The most consistent period of GH secretion for both children and young adults occurs about one hour after the onset of deep sleep (2).
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© 2001 Springer Science+Business Media New York
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Manelli, F., Volterrani, M., Lorusso, R., Romanelli, G., Giustina, A. (2001). Growth Hormone Secretion In Congestive Heart Failure. In: Giustina, A., Manelli, F. (eds) Growth Hormone And The Heart. Endocrine Updates, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1579-1_7
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DOI: https://doi.org/10.1007/978-1-4615-1579-1_7
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