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The Basal Transcription Apparatus

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Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control

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Abstract

Research on gene expression tends to focus on the factors which bind to enhancers and upstream promoter elements to provide specific regulation of a given gene. It is unclear, however, how any of these factors exert their influence to either activate or repress the target gene. The downstream target for all of these specific activators and repressors is the basal transcription apparatus, a set of proteins which is capable of mRNA synthesis from any RNA polymerase II promoter. In this review the functions of the individual basal transcription factors will be described, as well as the way upstream activating factors may influence the basal apparatus. The basal apparatus can be found in a pre-assembled complex, known as the RNA polymerase II holoenzyme, which contains other bridging factors that may link upstream activators to the basal machinery. Chromatin–remodeling proteins, which may be part of a holoenzyme, will be discussed in a holistic model of activator interactions with the basal transcription apparatus on chromatin templates.

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  1. Division of Molecular Oncology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Jeffrey D. Parvin & Stephen F. Anderson

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    Tucker Collins

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Parvin, J.D., Anderson, S.F. (2001). The Basal Transcription Apparatus. In: Collins, T. (eds) Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1565-4_7

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