The Metabolism of Lipoproteins

Abstract

Since the discovery of cholesterol at the end of the l8^thcentury, the multifactorial and heterogeneous nature of dyslipidemia has been a recurrent source of debate about their pathogenesis, implying alternately causal genetic and/or environmental factors. Indeed dyslipoproteinemia, commonly named dyslipidemia or lipid disorders, are disorders of the metabolism of lipoproteins circulating in human plasma. Their clinical manifestations may vary from highly specific and rare symptoms like cutaneous xanthoma, to the various forms of expression of atherosclerosis, whose cardiovascular complications are most prevalent in a growing number of populations worldwide.