Molecular Basis for Medicinal Actions of Androgens and Green Tea Epigallocatechin Gallate

  • Shutsung Liao
  • Yung-Hsi Kao
  • Mai T. Dang
  • Ching Song
  • Junichi Fukuchi
  • John M. Kokontis
  • Richard A. Hiipakka

Abstract

Androgens, which have been around for more than 2000 years, are probably the oldest drugs used in purified forms, while green tea extracts, which have been around for more than 3000 years, are among the most widely used ancient medicinal agents in man’s history. It is now clear that a specific green tea catechin, (-)epigallocatechin-3-gallate (EGCG), can regulate biological actions of androgens and other hormones. Androgens and EGCG can also modulate the growth of androgen-dependent and independent prostate cancers, as well as other hormone related abnormalities.

Keywords

Testosterone Catechin 5α-reductase Benign prostatic hyperplasia prostate cancer acne cell cycle arrest apoptosis food intake restriction obesity 

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Shutsung Liao
    • 1
  • Yung-Hsi Kao
    • 1
  • Mai T. Dang
    • 1
  • Ching Song
    • 1
  • Junichi Fukuchi
    • 1
  • John M. Kokontis
    • 1
  • Richard A. Hiipakka
    • 1
  1. 1.Tang Center for Herbal Medicine Research, Ben May Institute for Cancer Research and Department of Biochemistry and Molecular BiologyUniversity of ChicagoChicagoUSA

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