Molecular Basis for Medicinal Actions of Androgens and Green Tea Epigallocatechin Gallate
Androgens, which have been around for more than 2000 years, are probably the oldest drugs used in purified forms, while green tea extracts, which have been around for more than 3000 years, are among the most widely used ancient medicinal agents in man’s history. It is now clear that a specific green tea catechin, (-)epigallocatechin-3-gallate (EGCG), can regulate biological actions of androgens and other hormones. Androgens and EGCG can also modulate the growth of androgen-dependent and independent prostate cancers, as well as other hormone related abnormalities.
KeywordsTestosterone Catechin 5α-reductase Benign prostatic hyperplasia prostate cancer acne cell cycle arrest apoptosis food intake restriction obesity
Unable to display preview. Download preview PDF.
- Kao, Y. H., Hiipakka, R. A., and Liao, S. (2000). Modulation of obesity by a green tea catechin. Am. J. Clin. Nutr. In Press.Google Scholar
- Kokontis, J. M., Hay, N., and Liao, S. (1998) “Progression of LNCaP prostate tumor cells during androgen deprivation: Hormone-independent growth, repression of proliferation by androgen, and role for p27kip1 in androgen-induced cell cycle arrest” Mol. Endocrinol. 12, 941–953.PubMedCrossRefGoogle Scholar
- Liao, S., and Hiipakka, R. A. (1995). Selective inhibition of steroid 5α-reductase isoenzymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate. Biochem. Biophys. Res. Commun.Google Scholar
- Liao, S., Kao, Y. H., and Hiipakka, R. A. (2000) “Green tea: Biochemical and biological basis for health benefits” Vitamins and Hormones (in press).Google Scholar