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The Role of Inflammatory Mediators in the Failing Heart pp 49–57Cite as

Interactions Between Cytokines and Neurohormonal Systems in the Failing Heart

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 236))

Abstract

Congestive heart failure (CHF) remains an enormous health care problem in the United States, as well as other industrialized countries [1–3]. Millions of Americans are currently being treated for CHF and hundreds of thousands of others are expected to join their ranks annually. The prognosis for CHF patients has been improved as a result of the use of angiotensin converting enzyme inhibitors (ACEI) and β-adrenergic receptor blockers (β-blockers) [1–4]. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. It is now widely appreciated that norepinephrine (NE) and angiotensin II (AII) directly contribute to progressive deterioration in myocardial function and are not merely markers of disease severity or epiphenomenae [5–7].

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Author information

Authors and Affiliations

  1. Departments of Medicine (Cardiology), Robert C. Byrd Health Sciences Center, Louis A. Johnson V.A. Medical Center, Morgantown, WV, 26506-9157, USA

    Hong Kan MD, PhD & Mitchell S. Finkel MD

  2. Pharmacology and Toxicology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Louis A. Johnson V.A. Medical Center, Morgantown, WV, 26506-9157, USA

    Mitchell S. Finkel MD

Authors
  1. Hong Kan MD, PhD
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  2. Mitchell S. Finkel MD
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Douglas L. Mann M.D. (Director, Winters Center for Heart Failure Research, Gordon Cain Chair and Professor of Medicine) (Director, Winters Center for Heart Failure Research, Gordon Cain Chair and Professor of Medicine)

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Kan, H., Finkel, M.S. (2001). Interactions Between Cytokines and Neurohormonal Systems in the Failing Heart. In: Mann, D.L. (eds) The Role of Inflammatory Mediators in the Failing Heart. Developments in Cardiovascular Medicine, vol 236. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1449-7_6

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  • DOI: https://doi.org/10.1007/978-1-4615-1449-7_6

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-1449-7

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