The Control of Breathing at Rest
Breathing at rest is driven by two possible sources: behavioural, such as “wakefulness,” and metabolic, from the respiratory chemoreflexes that automatically control partial pressures of carbon dioxide and pH in the blood1–3. However, few measurements of the balance between these two drive sources at rest have been made, and some investigators suggest that behavioural drives may be more important than chemoreflex drives and sufficient to sustain resting breathing4,5.
KeywordsVentilatory Response Central Chemoreceptor Endogenous Circadian Rhythm Peripheral Chemoreflex Drive Source
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- 1.E. A. Phillipson, and G. Bowes. Control of breathing during sleep, in: Handbook of Physiology, Section 3,Volume 2, edited by A. P. Fishman (Bethesda MD: American Physiological Society, 1987), pp. 649–690.Google Scholar
- 2.J. Orem, and R. H. Trotter, Behavioral control of breathing. NIPS 9, 228–232 (1994).Google Scholar