Abstract
The mechanisms by which minute ventilation (VE) is tightly linked to the metabolic demands of exercising skeletal muscle remain uncertain. The idea that by-products of exercising muscle metabolism could stimulate peripheral afferent nerves communicating with regions of the central nervous system important in cardiorespiratory regulation (the skeletal muscle chemoreflex) is most compelling for the pressor response to exercise, but a growing body of literature suggests it is important in the control of ventilation as we.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Reference
Dempsey, J.A., Exercise hyperpnea. Adv. Exp. Med. Biol. 393(133): 133–136 (1995).
Coote, J.H., Hilton, S.M., and Perez-Gonzalez, J.F., The reflex nature of the pressor response to muscular exercise. J. Physiol. (Lond.) 215: 789–804 (1971).
Bennett, F.M., A role for neural pathways in exercise hyperpnea. J. Appl. Physiol. 56: 1559–1564 (1984).
Clark, A.L., Piepoli, M., and Coats, A.J.S., Skeletal muscle and the control of ventilation on exercise: evidence for metabolic receptors. Eur. J. Clin. Invest. 25: 299–305 (1995).
Eiken, O. and Bjurstedt, H., Dynamic exercise in man as influenced by experimental restriction of blood flow in the working muscles. Acta Physiol. Scand. 131: 339–345 (1987).
Rotto, D.M., Stebbins, C.L., and Kaufman, M.P., Reflex cardiovascular and ventilatory responses to increasing H’ activity in cat hindlimb muscle. J. Appl. Physiol. 67: 256–263 (1989).
Williamson, J.W., Raven, P.B., Foresman, B.H., and Whipp, B.J., Evidence for an intramuscular ventilatory stimulus during dynamic exercise in man. Respir. Physiol. 94(2): 121–135 (1993).
Adreani, C.M., Hill, J.M., and Kaufman, M.P., Responses of group III and IV muscle afferents to dynamic exercise. J. Appl. Physiol. 82(6): 1811–1817 (1997).
Kaufman, M.P., Longhurst, J.C., Rybicki, K.J., Wallach, J.H., and Mitchell, J.H., Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J. Appl. Physiol. 55: 105–112 (1983).
Mitchell, J.H. and Schmidt, R.F., Cardiovascular reflex control by afferent fibers from skeletal muscle receptors, in Handbook of Physiology. Cardiovascular System. Peripheral Circulation and Organ Blood Flow, J.T. Shepherd, F.M. Abbound, and S.R. Geiger, Editors. 1983, American Physiological Society: Bethesda. p. 623–658.
Rotto, D.M. and Kaufman, M.P., Effects of metabolic products of muscular contraction on the discharge of group III and IV afferents. J. Appl. Physiol. 64: 2306–2313 (1988).
Rybicki, K.J., Kaufman, M.P., Kenyon, J.L., and Mitchell, J.H., Arterial pressure responses to increasing interstitial potassium in hindlimb muscle of dogs. Am. J. Physiol. 247: R717–R721 (1984).
Beyaert, C.A., Hill, J.M., and Kaufman, M.P., Substance P analogues potentiate the pressor response to microinjection of L-glutamate into laminas I and II of the cat dorsal horn. Brain Res. 759(1): 175–179 (1997).
Li, J., Hand, G.A., Potts, J.T., Wilson, L.B., and Mitchell, J.H., c-Fos expression in the medulla induced by static muscle contraction in cats. Am. J. Physiol. 272: H48–55 (1997).
Hand, G.A., Potts, J.T., Treuhaft, B.S., Wilson, L.B., Petty, F., and Mitchell, J.H., Static muscle contraction elicits a baroreflex-dependent increase in glutamate concentration in the ventrolateral medulla. Brain Res 748(1–2): 211–218 (1997).
Ally, A., Hand, G.A., and Mitchell, J.H., Central injection of physostigmine attenuates exercise-induced pressor response in conscious cats. Am. J. Physiol. 273: R393–399 (1997).
McCloskey, D.I. and Mitchell, J.H., Reflex cardiovascular and respiratory responses originating in exercising muscle. J. Physiol. (Lond.) 224: 173–186 (1972).
Evans, A., Tsai, L.W., Oelberg, D.A., Kazemi, H., and Systrom, D.M., Skeletal muscle ECF pH error signal for exercise ventilatory control. J. Appl. Physiol. 84: 90–96 (1998).
Moon, R.B. and Richards, J.H., Determination of intracellular pH by 31P magnetic resonance. J. Biol. Chem. 248: 7276–7278 (1973).
Bangsbo, J., Johansen, L., Quistorff, B., and Saltin, B., NMR and analytic biochemical evaluation of CrP and nucleotides in the human calf during muscle contraction. J. Appl. Physiol. 74: 2034–2039 (1993).
Gadian, D.G., Nuclear Magnetic Resonance And Its Applications To Living Systems. 1982, New York: University Press.
Wildenthal, K., Mierzwiak, D.S., Skinner, N.S.J., and Mitchell, J.H., Potassium-induced cardiovascular and ventilatory reflexes from the dog hindlimb. Am. J. Physiol. 215: 542–548 (1968).
Piepoli, M., A.L., C., and Coats, A.J.S., Muscle metaboreceptors in hemodynamic, autonomic, and ventilatory responses to exercise in men. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1428–H1436 (1995).
Sargeant, A.J., Rouleau, M.Y., Sutton, J.R., and Jones, N.L., Ventilation in exercise studied with circulatory occlusion. J. Appl. Physiol. 50: 718–723 (1981).
Stanley, W.C., Lee, W.R., and Brooks, G.A., Ventilation studied with circulatory occlusion during two intensities of exercise. Eur. J. Appl. Physiol. 54: 269–277 (1985).
Comroe, J.H. and Schmidt, C.F., Reflexes from the limbs as a factor in the hyperpnea of muscular exercise. Am. J. Physiol. 138:536–547 (1943).
Systrom, D.M., Kanarek, D.J., Kohler, S.J., and Kazemi, H., “P nuclear magnetic resonance spectroscopy study of the anaerobic threshold in humans. J. Appl. Physiol. 68(5): 2060–2066 (1990).
Larson, D.E., Hesslink, R.L.,Hrovat, M.I., Fishman, R.S., and Systrom, D.M., Dietary effects on exercising muscle metabolism and performance by P-MRS. J. Appl. Physiol. 77: 1108–1115 (1994).
Oelberg, D.A., Evans, A.B., Hrovat, M.I., Pappagianopoulos, P.P., Patz, S., and Systrom, D.M., Skeletal muscle chemoreflex and pHi in exercise ventilatory control. J. Appl. Physiol. 84: 676–682 (1998).
Eldridge, F.L., Central integration of mechanisms in exercise hyperpnea. Med. Sci. Sports Exerc. 26: 319–327 (1994).
Eldridge, F.L. and Gill-Kumar, P., Central neural respiratory drive and afterdischarge. Respir. Physiol. 40: 49–63 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Systrom, D.M., Hrovat, M., Oelberg, D., Kazemi, H. (2001). Skeletal muscle chemoreflex in exercise Ventilatory control. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_55
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1375-9_55
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5522-9
Online ISBN: 978-1-4615-1375-9
eBook Packages: Springer Book Archive