Sustained Moderate Hyperoxia Augments the Acute Hypdxic Response in a Wake Goats
Sustained exposure to low oxygen induces a time-dependent increase in pulmonary ventilation that is termed ventilatory acclimatization to hypoxia (VAH). The time it takes for this increase in ventilation to reach a stable plateau varies greatly across species but in the goat it occurs in about 4-6 h1. Previous reports in the goat have indicated that this process is not only dependent on intact carotid bodies (CB)2, but also on the progressive increase in CB output that occurs with prolonged hypoxic but not hypercapnic stimulation3,4. It is unclear, however, whether or not acclimatization occurs over an oxygen continuum or whether it is strictly a function of a hypoxic stimulus.
KeywordsToxicity Attenuation Carbon Monoxide Cyanide Methysergide
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