Abstract
Acute hypoxia decreases VO2in small mammals.1The magnitude of the fall in V02is related to the age of the animal, the level of hypoxia and the degree of development at birth.1In addition to the fall in Vo2with exposure to acute hypoxia, ventilation changes by first increasing from peripheral chemoreceptor stimulation and then decreasing in a time-dependent manner. The mechanism of such “roll-off”, or hypoxic ventilatory decline (HVD), is not fully understood.2 Although the carotid bodies are required for the increase in ventilation during the hypoxic ventilatory response, they are not necessary for the decrease in metabolism that occurs with hypoxia.1We propose calling this the hypoxic metabolic response (HMR), by analogy to the hypoxic ventilatory response (HVR).
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References
J.P. Mortola and H. Gautier, Interaction between metabolism and ventilation: Effects of respiratory gases and temperature, in: Regulation of Breathing, edited by J.A. Dempsey and A.I. Pack (Marcel Dekker, New York, 1995), pp. 1011–1064.
G.E. Bisgard and J.A. Neubauer, Peripheral and central effects of hypoxia, in: Regulation of Breathing, edited by J.A. Dempsey and A.I. Pack (Marcel Dekker, New York, 1995), pp. 617–668.
I. Soto-Arape, M.D. Burton, and H. Kazemi, Central amino acid neurotransmitters and the hypoxic ventilatory response, Am. J. Respir. Crit. Care Med. 151:1113–1120 (1995).
B. Hoop, J.L. Beagle, T.J. Maher, and H. Kazemi, Brainstem amino acid neurotransmitters and hypoxic ventilatory response, Respir. Physiol. 118:117–129 (1999).
J. Huang, C. Suguihara, D. Hehre, J. Lin, and E. Bancalari, Effects of GABA receptor blockade on the respiratory response to hypoxia in sedated newborn piglets, J. Appl. Physiol., 77:1006–1010 (1994).
M.P. Kneussl, P. Pappagianopoulus, B. Hoop, and H. Kazemi, Effect of centrally administered γaminobutyric acid on metabolic function, J. Appl. Physiol. 61:472–476 (1986).
H.V. Forster, P.J. Ohtake, L.G. Pan, and T.F. Lowry, and P. Martino, Effect of breathing of surface ventrolateral medullary cooling in awake, anesthetized and asleep goats, Respir. Physiol. 110:187–197 (1997).
J.A. Neubauer, J.E. Melton, and N.H. Edelman, Modulation of respiration during brain hypoxia, J. Appl. Physiol. 68:441–451 (1990).
F.L. Powell, W.K. Milsom, and G.S. Mitchell, Time domains of the hypoxic ventilatory response, Respir. Physiol. 112:123–134 (1998).
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Dwinell, M.R., Kazemi, H., Lam, J.T., Powell, F.L. (2001). Central Amino Acid Neurotransmitters, Ventilatory Output and Metabolism During Acute Hypdxia in Anesthetized Rats. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_46
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DOI: https://doi.org/10.1007/978-1-4615-1375-9_46
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