Modeling the Interaction Between Perfusion Pressure and CO2 on Cerebral Blood Flow

  • Michael R. Edwards
  • D. C. Lin
  • Richard L. Hughson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 499)


It is well recognized that steady state changes in cerebral perfusion pressure (CPP) and arterial CO2 (PCO2) alter cerebral blood flow (CBF). With the advent of Doppler ultrasound, a more dynamic understanding of how these variables affect CBF can now be investigated. Recently, several authors have characterized spontaneous, beat-by-beat changes in CPP on CBF using frequency domain analyses,1,2 However, since PCO2 shows its own pattern of variability, these authors have failed in their analysis to consider the impact of spontaneous, breath-by-breath oscillations in PCO2 on CBF.


Cerebral Blood Flow Cerebral Perfusion Pressure Spontaneous Breathing Step Response High Frequency Region 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Michael R. Edwards
    • 1
  • D. C. Lin
    • 1
  • Richard L. Hughson
    • 2
  1. 1.Department of Kinesiology, University of WaterlooCardiorespiratory and Vascular Dynamics LabWaterlooCanada
  2. 2.Ryerson Polytechnical UniversityTorontoCanada

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