Modeling the Interaction Between Perfusion Pressure and CO2 on Cerebral Blood Flow
It is well recognized that steady state changes in cerebral perfusion pressure (CPP) and arterial CO2 (PCO2) alter cerebral blood flow (CBF). With the advent of Doppler ultrasound, a more dynamic understanding of how these variables affect CBF can now be investigated. Recently, several authors have characterized spontaneous, beat-by-beat changes in CPP on CBF using frequency domain analyses,1,2 However, since PCO2 shows its own pattern of variability, these authors have failed in their analysis to consider the impact of spontaneous, breath-by-breath oscillations in PCO2 on CBF.
KeywordsCerebral Blood Flow Cerebral Perfusion Pressure Spontaneous Breathing Step Response High Frequency Region
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- 3.B. J. Whipp, N. Lamarra, S. A. Ward, J. A. Davis, and K. Wasserman, Estimating arterial PCO2 from flow-weighted and time-averaged alveolar PCO2 during exercise, in: Respiratory Control: A Modeling Perspective, edited by G. D. Swanson, F. S. Grodins, and R. L Hughson (Plenum Press, New York, 1991), pp. 91–99.Google Scholar