Activation of Medullary Post-Inspiratory Related Neurons During Clonidine-Induced Central Apnea in Anesthetized Goats

  • Ken D. O’Halloran
  • Jay K. Herman
  • Gerald E. Bisgard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 499)


α2-adrenoceptors (α2-ARs) are widely distributed in the CNS including brainstem sites associated with cardiorespiratory control. 1,2 Several lines of evidence strongly suggest a role for α2-ARs in the regulation of respiratory rhythm. We have recently demonstrated that systemic administration of clonidine and other α2-AR agonists cause profound disturbances in respiratory pattern in the goat that are characterized by alternating episodes of tachypnea and respiratory depression (prolonged and variable expiratory time intervals).3-8 Dysrhythmic breathing induced by α2-AR agonists in the goat is associated with continuous tonic activation of expiratory-related drive in laryngeal4,5 and pharyngeal motoneurons6,8 leading to active airway closure during central apnea.6,8


Recurrent Laryngeal Nerve Respiratory Rhythm Central Apnea Phrenic Nerve Activity Ventilatory Disturbance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Ken D. O’Halloran
  • Jay K. Herman
  • Gerald E. Bisgard
    • 1
  1. 1.Department of Comparative BiosciencesSchool of Veterinary Medicine, University of WisconsinMadisonUSA

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