Abstract
The importance of peripheral chemoreceptors, especially the carotid bodies in control of breathing during hypoxia is being increasingly appreciated. Currently there are two views as to how hypoxia augments carotid body activity1. According to one view, a redox sensitive protein in the glomus cell is the oxygen sensor, and a variety of mitochondria) and non-mitochondrial redox-sensitive proteins have been proposed as potential 02 sensors. The other view assumes that a K+ channel in glomus cell is the primary 02 sensor. The most challenging question is whether transduction involves a “single” or “multiple” 02 sensors’. It is more than likely that multiple sensors are needed for oxygen sensing allowing the carotid body to respond to a wide range of arterial P02’s resulting in a curvilinear stimulus-response curve.
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References
N. R. Prabhakar. Oxygen sensing by the carotid body chemoreceptors. J. Appl. Physiol. 88: 2287–2295, (2000).
S. Lahiri and R.G. DeLaney. Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibers, Respir. Physiol. 24, 249–266 (1975).
A. Roy, C. Rozanov, A. Mokashi, and S. Lahiri. P02–PCO2 stimulus interaction in [Ca 2+]i and CSN activity in the adult rat carotid body. Respir. Physiol. 122: 15–26, (2000).
K.M. Spyer and T. Thomas. Sensing arterial CO2 levels: a role for medullary P2X receptors. J.Auton. Nerv. Syst. 81:228–235, (2000).
R.S. Fitzgerald, R.S. and D. Parks. Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats. Respir Physiol 12: 218–229, (1971).
Dasso, L.L, K.J. Buckler, and R.D. Vaughan-Jones. Interactions between hypoxia and hypercapnic acidosis on calcium signaling in carotid body type I cells. Am. J. Physiol. Lung Cell Mol Physiol 279: L36–L42, (2000).
R.S. Fitzgerald. Oxygen and carotid body chemotransduction: the cholinergic hypothesis - a brief history and new evaluation. Respir Physiol 120: 89–104, (2000).
Zhang, M., H. Zhong, C. Vollmer, and C.A. Nurse. Co-release of ATP and ACh mediates hypoxic signaling at rat carotid body chemoreceptors. J. Physiol (London) 525: 143–158, (2000).
E. E. Nattie. Central chemoreceptors, pH, and respiratory control, in: PH and Brain Function, edited by K. Kaila and B. R. Ransom (John Wiley and Sons, Inc., New York, 1998), pp 535–560.
E. E. Nattie. CO2, brainstem chemoreceptors, and breathing, Prog Neurobiol 59, 299–331 (1999).
E. Nattie. Multiple sites for central chemoreception: their roles in response sensitivity and in sleep and wakefulness, Respir. Physiol. 122, 223–235, (2000).
A. Li, M. Randall, and E. E. Nattie. CO2 microdialysis in the retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep, J Appl Physiol 87, 910–919, (1999).
A. Li and E. E. Nattie. CO2 microdialysis in the raphe of the unanesthetized rat increases breathing in sleep, J Appl Physiol (in press) (2001).
I.D. Clement, J.J. Pandit, D.A. Bascom, K.L. Dorrington, D.F. O’Connor, and P.A. Robbins. An assessment of central-peripheral ventilatory chemoreflex interaction using acid and bicarbonate infusions in humans, J. Physiol.,485, 561–570 (1995).
J.H.G.M. van Beek, A. Berkenbosch, J. de Goede, and C.N. Olievier. Influence of peripheral 02 tension on the ventilatory response to CO2 in cats,Respir. Physiol 51, 379–390 (1983).
J. P. Miller, D.J.C. Cunningham, B.B. Lloyd, and J.M. Young. The transient respiratory effects in man of sudden changes in alveolar CO2 in hypoxia and in high oxygen, Respir. Physiol 20, 17–31 (1974).
M. E. F. Pedersen, M. Fatemian, and P.A. Robbins. Identification of fast and slow ventilatory responses to carbon dioxide under hypoxic and hyperoxic conditions in humans, J. Physiol. 521, 273–287 (1999).
M. A. Fatemian, A. Dahan, S. Meinesz, A. van der Mey, and P.A. Robbins, Modelling the bilateral carotid body resection, in: Frontiers in Modeling and Control of Breathing: Integration at Molecular Cellular and Systems Levels, edited by C-S. Poon. New York: Kluwer Academic/Plenum, 2000, p. submitted.
J. W. Bellville, B.J. Whipp, R.D. Kaufman, G.D. Swanson, K.A. Aqleh, and D.M. Wiberg. Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects, J. Appl. Physiol . 46, 843–853 (1979).
L. G. Pan, H.V. Forster, P. Martino, P.J. Strecker, J. Beales, A. Serra, T.F. Lowry, M.M. Forster, and A. L. Forster. Important role of carotid afferents in control of breathing. J. Appl. Physiol. 85, 1299–1306 (1998).
T. F. Lowry, H. V. Forster, L. G. Pan, M. A. Korducki, J. Probst, R. A. Franciosi, and M. Forster. Effect of carotid body denervation on breathing in neonatal goats, J. Appl Physiol 87, 1026–34 (1999).
T. F. Lowry, H. V. Forster, L. G. Pan, A. Serra, J. Wenninger, R. Nash, D. Sheridan, and R. A. Franciosi. Effects on breathing of carotid body denervation in neonatal piglets, J Appl Physiol 87, 2128–35 (1999).
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Nattie, E.E., Prabhakar, N.R. (2001). Peripheral and Central Chemosensitivity: Multiple Mechanisms, Multiple Sites?. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_12
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