Peripheral and Central Chemosensitivity: Multiple Mechanisms, Multiple Sites?
The importance of peripheral chemoreceptors, especially the carotid bodies in control of breathing during hypoxia is being increasingly appreciated. Currently there are two views as to how hypoxia augments carotid body activity1. According to one view, a redox sensitive protein in the glomus cell is the oxygen sensor, and a variety of mitochondria) and non-mitochondrial redox-sensitive proteins have been proposed as potential 02 sensors. The other view assumes that a K+ channel in glomus cell is the primary 02 sensor. The most challenging question is whether transduction involves a “single” or “multiple” 02 sensors’. It is more than likely that multiple sensors are needed for oxygen sensing allowing the carotid body to respond to a wide range of arterial P02’s resulting in a curvilinear stimulus-response curve.
KeywordsCarotid Body Ventilatory Response Glomus Cell Peripheral Chemoreceptor Carotid Body Chemoreceptor
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