Advertisement

Long-Chain Polyunsaturated Fatty Acids (LC-PUFA) During Early Development

Contribution of Milk LC-PUFA to Accretion Rates Varies Among Organs
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 501)

Abstract

Long-chain polyunsaturated fatty acids (LC-PUFA) accretion (essential for growth and neural development) was studied from late fetal throughout weaning age in the ferret, a species with maternal LC-PUFA sufficiency during pregnancy and lactation. The data show that a) accretion rate of LC-PUFA is rapid during early postnatal development, b) milk LC-PUFA decrease during lactation, c) adipose tissur, LC-PUFA level is directly related to milk LC-PUFA level, while accretion in brair and liver exceeds dietary intake, d) accretion of arachidonic acid occurs earlier than docosahexaenoic acid, suggesting earlier development of n6-fatty acid endogenous synthesis.

Keywords

Arachidonic Acid Human Milk Accretion Rate Chain Polyunsaturated Fatty Acid Arachidonic Acid Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bindels JG, Goedhart AC, Visser HKA, editors. Recent Developments in Infant Nutrition. Dordrecht: Kluwer Academic Publications; 1996.Google Scholar
  2. Crawford M, Marsh D. Nutrition and Evolution. New Canaan CT: Keats Publishing; 1995.Google Scholar
  3. Dobbing J, editor. Developing Brain and Behaviour. San Diego: Academic Press, 1997.Google Scholar
  4. Ellis LA, Hamosh M. Bile salt stimulated lipase: comparative studies in ferret milk and lactating mammary gland. Lipids 1992;27:917–922.PubMedCrossRefGoogle Scholar
  5. Farquharson J, Cockburn F, Patrick WA, Jamieson EC, Logan RW. Infant cerebral cortex phosopholipid fatty acid composition and diet. Lancet 1992;340:810–813.PubMedCrossRefGoogle Scholar
  6. Gil A, Henderson TR, Hamosh M. Is the newborn preferentially storing long chain polyunsaturated fatty acids (LC-PUFA) or are maternal reserves depleted during lactation? Pediatr Res 1995;37:308A.Google Scholar
  7. Hamosh M. Digestion in the neonate. Clin Perinatol 1996;23:191–209.PubMedGoogle Scholar
  8. Hamosh M, Henderson TR, Hayman L. Long chain unsaturated fatty acids in human milk during prolonged lactation. FASEB J 1996;10:A516.Google Scholar
  9. Hamosh M, Henderson TR, Hamosh P. Gastric lipase and pepsin activities in the developing ferret: nonparallel development of the two gastric digestive enzymes. J Pediatr Gastroenterol Nutr 1998; 26:162–166.PubMedCrossRefGoogle Scholar
  10. Henderson TR Fay T Hamosh M. Effect of pasteurization on long chain polyunsaturated fatty acid levels and enzyme activities in human milk. J Pediatr 1998;132:876–878.PubMedCrossRefGoogle Scholar
  11. Holman RT, Johnson SB, Ogburn PL. Deficiency of essential fatty acids and membrane fluidity during pregnancy and lactation. Proc Soc Natl Acad Sci USA 1991;88:4835–4839.CrossRefGoogle Scholar
  12. Hornstra G, Van Houwelingen AC, Simonis M, Gerrard JM. Fatty acid composition of umbilical arteries and veins: possible implications for the fetal EFA status. Lipids 1989;24:511–517.PubMedCrossRefGoogle Scholar
  13. Hornstra G, Al MD, Van Houwelingen AC, Foreman-van Drongelen MM. Essential fatty acids, pregnancy and pregnancy outcome. In: Bindels JG, Goedhart AC, Visser HKA, editors. Recent Developments in Infant Nutrition. Dordrecht: Kluwer Academic Publications; 1996. pp. 51–63.CrossRefGoogle Scholar
  14. Iverson SJ, Kirk CL, Hamosh M, Newsome J. Milk lipid digestion in the neonatal dog: the combined actions of gastric and bile salt stimulated lipases. Biochim Biophys Acta 1991;1083:109–119.PubMedCrossRefGoogle Scholar
  15. Luukkainen P, Salo MK, Nikkari T.Changes in fatty acid composition of preterm and term milk from 1 week to 6 months of lactation. J Pediatr Gastroenterol Nutr 1994;18:355–360.PubMedCrossRefGoogle Scholar
  16. Makrides M, Neuman NMA, Byard RW, Simmer K, Gibson RA. Fatty acid composition of brain, retina and erythrocytes in breast and formula fed infants. Am J Clin Nutr 1994;60:189–194.PubMedGoogle Scholar
  17. Salem N Jr, Wegher B, Mena P, Uauy R. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc Natl Acad Sci USA 1996;93:49–54.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  1. 1.Departments of Pediatrics and Physiology and Biophysics Georgetown University Medical Center

Personalised recommendations

Cite chapter

Buy options