Glycobiological Approach to Control of Retinal Degeneration

  • Fumiyuki Uehara
  • Norio Ohba
  • Masayuki Ozawa


Medical treatment of degenerative disorders of the central nervous system has been attempted using a number of neurotrophic agents. In the rat retina, direct injection of growth factors or neurotrophic factors into the eye delays photoreceptor degeneration in inherited retinal dystrophy (Faktorovich et al., 1990) and light damage (Faktorovich et al., 1992). Although a combination of different factors enhances the degree of photoreceptor survival (LaVail et al., 1992), the effects of other types of agents should be examined to determine the perfect combination.


Photoreceptor Cell Retinal Degeneration Outer Nuclear Layer Maltose Binding Protein Inner Nuclear Layer 
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  1. Akahani, S., Nangia-Makker, P., Inohara, H., Kim, H.R., and Raz, A., 1997, Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family,Cancer Res.57: 5272–5276.PubMedGoogle Scholar
  2. Albrand, K.A., Orida, N.K., and Liu, F.T., 1987, An IgE-binding protein with a distinctive repetitive sequence and homology with an IgG receptor,Proc. Natl. Acad. Sci. USA.84:6859–6863.CrossRefGoogle Scholar
  3. Barondes, S.H., Cooper, D.N.W., Gitt, M.A., and Leffler, H., 1994, Galectins, stracture and function of a large family of animal lectins,J. Biol.Chem.269:20807–20810.PubMedGoogle Scholar
  4. Chang, G.Q., Hao, Y., and Wong, F., 1993, Apoptosis: Final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice,Neuron 11: 595–605.PubMedCrossRefGoogle Scholar
  5. Eisenfeld, A. J., Bunt-Milam, A.H., and Sarthy, P.V., 1984, Mueller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina,Invest. Ophthalmol. Vis. Sci 25:1321–1328.PubMedGoogle Scholar
  6. Faktorovich, E.G., Steinberg, R.H., Yasumura, D., Matthes, M.T., and LaVail, M.M., 1990, Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor,Nature 347: 83–86.PubMedCrossRefGoogle Scholar
  7. Faktorovich, E.G., Steinberg, R.H., Yasumura, D., Matthes, M.T., and LaVail, M.M., 1992, Basic fibroblast growth factor and local injury protect photoreceptors from constant light damage in the rat,J. Neurosci.12: 3554–3567.PubMedGoogle Scholar
  8. Jia, S., and Wang, J.L., 1988, Carbohydrate binding protein 35: Complementary DNAsequence reveals homology with proteins of the heterogeneous nuclear RNP,J. Biol. Chem.263: 6009–6011.PubMedGoogle Scholar
  9. LaVail, M.M., Gorrin, G.M., Repaci, M.A., Thomas, L.A., and Ginsberg, H.M., 1987, Genetic regulation of light damage to photoreceptors,Invest. Ophthalmol. Vis. Sci.28: 1043–1048.PubMedGoogle Scholar
  10. LaVail, M.M., Unoki, K., Yasumaura, D., Matthes, M.T., et al., 1992, Multiple growth factors, cytokines and neurotrophins rescue photoreceptors from the damaging effets of constant light,Proc. Natl. Acad. Sci. USA.89: 11249–11253.PubMedCrossRefGoogle Scholar
  11. Oda, Y., Leffler, H., Sakakura, Y., Kasai, K., and Barondes, S.H., 1991, Human breast carcinoma cDNA encoding a galactose-binding lectin homologous to mouse Mac-2 antigen,Gene.99:279–283.PubMedCrossRefGoogle Scholar
  12. Ozawa, M., Terada, H., and Pedraza, C., 1995, The fourth armadillo repeat of plakoglobin (-catenin) is required for its high affinity binding to the cytoplasmic domains of E-cadherin and desmosomal cadherin Dsg2, and the tumor suppressor APC protein,J. Biochem.118:1077–1082.PubMedCrossRefGoogle Scholar
  13. Uehara, F., Muramatsu, T., Ozawa, M., Koide, H., et al., 1986, Purification of antibody against peanut agglutinin-receptors of bovine interphotoreceptor matrix,Jpn. J. Ophthalmol.30: 56–62.PubMedGoogle Scholar
  14. Uehara, F., Sameshima, M., Takumi, K., Unoki, K., et al., 1988, Sialic acid in the retina and its significance in the retinal degeneration, in:Glycoconjugates in Medicine, M. Ohyama, ed., Professional Postgraduate Services, Tokyo, pp. 310–315.Google Scholar
  15. Uehara, F., Ohba, N., Sameshima, M., Takumi, K., et al., 1989, Nucleotide induced retinal changes, in:Inherited and Environmentally Induced Retinal Degenerations, M.M. La Vail, R.E. Anderson, and J.G. Hollyfield, ed., Alan R. Liss, New York, pp. 577–583.Google Scholar
  16. Uehara, F., Ohba, N., Sameshima, M., Yanagita, T., et al., 1996, Sialoglycoconjugates and retinal degeneration, in:Retinal Degeneration and Regeneration, S. Kato, N.N. Osborne and M. Tamai, ed., Kugler Publications, Amsterdam, pp. 73–80.Google Scholar
  17. Uehara, F., Ohba, N., Yanagita, T., Sameshima, M., et al., 1997, Glycohistochemical study of light-induced retinal degeneration, in:Degenerative Retinal Diseases, M.M. La Vail, J.G. Hollyfield and R.E. Anderson, ed., Plenum Press, New York, pp.181–191.CrossRefGoogle Scholar
  18. Uehara, F., Ohba, N., and Ozawa, M., 2000, Isolation and characterization of mucinlike glycoprotein associated with photoreceptor cells,Invest. Ophthalmol Vis. Sci.41:2759–2765.PubMedGoogle Scholar
  19. Uga, S., and Smelser, G.K., 1973, Comparative study of the fine structure of retinal Mueller cells in various vertebrates,Invest. Ophthalmol.12:434–448.PubMedGoogle Scholar
  20. Unoki, K., Ohba, N., Arimura, H., Muramatsu, H., and Muramatsu, T., 1994, Rescue of photoreceptors from the damaging effects of constant light by midkine, a retinoic acid-responsive gene product,Invest. Ophthalmol. Vis. Sci.35:4063–4068.PubMedGoogle Scholar
  21. Yang, R.Y., Hsu, D.K., and Liu, F.T., 1996, Expression of galectin-3 modulates T-cell growth and apoptosis,Proc. Natl. Acad. Sci. USA.25: 6737–6742.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Fumiyuki Uehara
    • 1
  • Norio Ohba
    • 1
  • Masayuki Ozawa
    • 2
  1. 1.Department of OphthalmologyKagoshima University Faculty of MedicineKagoshima-shiJapan
  2. 2.Department of BiochemistryKagoshima University Faculty of MedicineKagoshima-shiJapan

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