Aqueous Solubility of Weak Acids and Bases

A chameleon in disguise
  • William H. Streng


During my formative years I did not have the opportunity to visit areas which had tropical or subtropical climates. Almost all of my activities were in the humid continental climate zone with brief excursions into the subarctic and middle-latitude desert and steppe climate zones. After I had started graduate school, I had the opportunity to experience, with much delight, the world which exists in the humid subtropical and tropical savanna climate zones. On the surface nothing seemed much different. This trip occurred during the winter months and there was snow on the ground where I left and the temperatures were about 30 °C (86 °F) where I was visiting, but beyond this there did not appear to be anything strikingly different. However, upon closer scrutinization, I found that there were many things which were not the same. Hanging from the trees, high voltage wires and phone lines was Spanish moss - a plant which grows on other plants but which gets its food, water and minerals from the air. There were many birds around but these species were much different from those I was accustomed to seeing. While there were deciduous and conifer trees, again the species were much different. I was not familiar with the salt water fish since all of my fishing experience had been in fresh water lakes. Lastly, some of the mammals encountered were quite different ranging from the manatee, found in the bayous and tributaries along the ocean, to alligators.


Gibbs Free Energy Activity Coefficient Weak Acid Aqueous Solubility Infinite Dilution 
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  1. Popovych, O. and Tomkins, R.P.T., Nonaqueous Solution Chemistry, (1981), John Wiley and SonsGoogle Scholar
  2. Streng, W.H., The Gibbs constant and pH solubility profiles, International J. Pharmaceutics,756,137–140(1999)CrossRefGoogle Scholar
  3. Streng, W.H. and Tan, H.G.H., General treatment ofpH solubility profiles of weak acids and bases. II. Evaluation of thermodynamic parameters from the temperature dependence of solubility profiles applied to a zwitterionic compound, International J. Pharmaceutics,25,135–145(1985)CrossRefGoogle Scholar
  4. Streng, W.H., et al., General treatment ofpH solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base, J Pharmaceutical Sciences,73,1679–1684(1984)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • William H. Streng
    • 1
  1. 1.Quintiles, Inc.Kansas CityUSA

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