Solid Organ Transplantation

  • Alan Reed
  • Maher A. Baz
  • LeAnne McGinn
  • Richard S. Schofield


Transplantation has become the therapeutic option of choice for most causes of liver or kidney failure; transplantation of the pancreas (with or without a concomitant kidney transplant) has become an acceptable option for the treatment of type I diabetes mellitus (with or without renal failure); transplantation of the lungs has been used successfully to treat emphysema and cystic fibrosis; and transplantation of the heart has become very effective in treating cardiomyopathy and other end-stage cardiac disorders. While these statements can be made with conviction today, and are based on factual evidence, they may well change tomorrow. Perhaps the most fascinating aspect of organ transplantation has been that its course is always evolving. The standard of care for transplant recipients changes with each new discovery. Nowhere in medicine is the relationship between the basic science laboratory and the bedside more closely linked. Similarly, nowhere is the psychological make-up and social milieu in which the patient functions more closely associated with success than in organ transplantation. Transplantation is one of the first fields in health care to be closely monitored by the federal government and for which a shared database has been congressionally mandated. This is why transplantation is an exciting and interesting challenge to physicians, nurses, psychologists, social workers, and other involved personnel.


Cystic Fibrosis Liver Transplantation Heart Transplantation Graft Survival Lung Transplantation 
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  1. Abendroth, D., Landgraf, R., Illner, W., & Land, W. (1989). Evidence for reversibility of diabetic microangiopathy following pancreas transplantatioa Transplantation Proceedings; 21, 2850–2851.PubMedGoogle Scholar
  2. Bando, K., Paradis, I.L., Similo, S., Konishi, H., Komatsu, K., Zullo, T.G., Yousem, S.A., Close, J.M., Zeevi, A., Duquesnoy, R.J., Manzetti, J., Keenan, R.J., Armitage, J.M., Hardesty, R.L., & Griffith, B.P. (1995). Obliterative bronchiolitis after lung and heart-lung transplantation: An analysis of risk factors and management. Journal of Thoracic and Cardiovascular Surgery, 110, 4–14.PubMedCrossRefGoogle Scholar
  3. Barnard, C.H. (1967). A human cardiac transplant: An interim report of a successful operation performed at Groote Schuur Hospital, Capetown. South African Medical Journal, 41, 1271–1274.PubMedGoogle Scholar
  4. Bartlett, S. (1999). Results of 295 laparoscopic live donor kidney transplants at one institution. Paper presented at the 25th Annual Meeting of the American Society of Transplant Surgeons, Chicago, IL.Google Scholar
  5. Becker, A. and H. Sollinger. in American Society of Nephrology. 1999. Washington, DC.Google Scholar
  6. Belzer, F. (1991). Organ preservation: A personal perspective. In P. Terasaki (ed.), History of transplantation: Thirty-five recollections. Los Angeles: UCLA Tissue Typing Laboratory.Google Scholar
  7. Billingham, R.E., Brent, L., & Medawar, P.B. (1963). Actively acquired tolerance of foreign cells. Nature, 172, 603–606.CrossRefGoogle Scholar
  8. Bilous, R., Mauer, S., & Sutherland, D. (1989). The effects of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes. New England Journal of Medicine, 321, 80–85.PubMedCrossRefGoogle Scholar
  9. Brent, L. (1997). A history of transplantation immunology. San Diego: Academic Press.Google Scholar
  10. Broelsch, C., Emond, J.C., Whitington, P.F., Thistlethwaite, J.R., Baker, A.L., & Lichtor, J.L. (1990). Application of reduced size liver transplants as split grafts, auxiliary orthotopic grafts, and living related segmental transplants Annals of Surgery, 214, 368–377.CrossRefGoogle Scholar
  11. Broelsch, C., Whitington, P.F., Emond, J.C., Heffron, T.G., Thistlethwaite, J.R., Stevens, L., Piper, J., Whitington, S.H., & Lichtor, J.L. (1991). Liver transplantation in children from living related donors: Surgical techniques and results. Annals of Surgery, 214, 428–439.PubMedCrossRefGoogle Scholar
  12. Caves, P.K., Stinson, E.B., Graham, A.F., Billingham, M.E., Grehl, T.M., & Shumway, N.E. (1973). Percutaneous transvenous endomyocardial biopsy. Journal of the American Medical Association, 225, 288–291.PubMedCrossRefGoogle Scholar
  13. Chaparro, C, Maurer, J.R., Chamberlain, D., De Hoyos, A., Winton, T., Westney, G., & Kesten, S. (1994). Causes of death in lung transplant patients. Journal of Heart and Lung Transplantation, 13, 758–766.PubMedGoogle Scholar
  14. Dauber, J.H., Paradis, I.L., & Dummer, J.S. (1990). Infectious complications in pulmonary allograft recipients. Clinical Chest Medicine, 11, 291–307.Google Scholar
  15. Davis, R.D., & Pasque, M.K. (1995). Pulmonary transplantation. Annals of Surgery, 221, 14–28.PubMedCrossRefGoogle Scholar
  16. Dong, E., Hurley, E.J., Lower, R.R., & Shumway, N.E. (1964). Performance of the heart two years after auto transplantation. Surgery, 56, 270–274.PubMedGoogle Scholar
  17. Ghobrial, R. (1999). In situ splitting of the donor liver. Paper presented at the Living Donor and Split Liver Transplantation Symposium, Pittsburgh, PA.Google Scholar
  18. Griffith, B.P., Paradis, I.L., Zeevi, A., Rabinowich, H., Yousem, S.A., Duquesnoy, R.J., Dauber, J.H., & Hardesty, R.L. (1988). Immunologically mediated disease of the airways after lung transplantation. Annals of Surgery, 208, 371–378.PubMedCrossRefGoogle Scholar
  19. Hardy, J.D., Chavez, C.M., Kurrus, F.D., Neely, W.A., Eraslan, S., Turner, M.D., Fabian, L.W., & Labecki, T.D. (1964). Heart transplantation in man: Developmental studies and report of a case. Journal of the American Medical Association, 188,1132–40.PubMedCrossRefGoogle Scholar
  20. Hardy, J.D., Webb, W.R., Dalton, M.L., & Walker, G.R. (1963). Lung homotransplantation in man: Report of the initial case. Journal of the American Medical Association, 186, 1065–1074.PubMedCrossRefGoogle Scholar
  21. Hosenpud, J.D., Bennett, L.E., Keck, B.M., Fiol, B., Boucek, M.M., & Novick, R.J. (1999). The registry of the international society for heart and lung transplantation: Sixteenth official report - 1999. Journal of Heart and Lung Transplantation, 18, 611–626.PubMedCrossRefGoogle Scholar
  22. Keller, C.A., Cagle, P.T., Brown, R.W., Noon, G., & Frost, A.E. (1995). Bronchiolitis obliterans in recipients of single, double, and heart-lung recipients. Chest, 107, 973–980.PubMedCrossRefGoogle Scholar
  23. Kelly, W., Lillehei, R.C., Merkel, F.K., Idezuki, Y., & Goetz, F.C. (1967). Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery, 61, 827–837.PubMedGoogle Scholar
  24. Kennedy, W., Navarro, X., Goetz, F.C, Sutherland, D.E., & Najarian, J.S. (1990). Effects of pancreatic transplantation on diabetic neuropathy. New England Journal of Medicine, 322, 1031–1037.PubMedCrossRefGoogle Scholar
  25. Laupacis, A., Keown, P., Pus, N., Krueger, H., Ferguson, B., Wong, C., & Muirhead, N. (1996). A study of the quality of life and cost-utility of renal transplantatioa Kidney International, 50, 235–242.PubMedCrossRefGoogle Scholar
  26. Marcos, A. (2000). Right lobe living donor liver transplantation: A review. Liver Transplantation, 6, 3–20.PubMedGoogle Scholar
  27. Marshall, P.A., & Daar, A.S. (1998). Cultural and psychological dimensions of human organ transplantation. Annals of Transplantation, 3, 7–11.PubMedGoogle Scholar
  28. Maurer, J.R., Frost, A.E., Estenne, M., Higgenbottam, T., & Glanville, A.R. (1998). International guidelines for the selection of lung transplant candidates. Journal of Heart and Lung Transplantation, 17, 703–709.PubMedGoogle Scholar
  29. Merrill, J., Murray, J.E., Harrison, J.H., & Guild, W.R. (1956). Successful homotransplantation of the human kidney between identical twins. Journal of the American Medical Association, 160, 277–282.PubMedCrossRefGoogle Scholar
  30. Moore, F. (1988). The history of transplantation: A lesson for our time. In G. Cerilli (ed.), Organ transplantation and replacement (pp. 3–15). Philadelphia: J.B. Lippincott Co.Google Scholar
  31. Nakache, R., Tyden, G., & Groth, C. (1989). Quality of life in diabetic patients after combined pancreas-kidney or kidney transplantatioa Diabetes, 38, 40–42.PubMedGoogle Scholar
  32. Nathan, S.D., Ross, D.J., Belman, M.J., Shain, S., Elashoff, J.D., Kass, R.M., & Koerner, S.K. (1995). Bronchiolitis obliterans in single-lung transplant recipients. Chest, 107, 967–972.PubMedCrossRefGoogle Scholar
  33. Navarro, X., Kennedy, W.R., Loewenson, R.B., & Sutherland, D.E. (1990). Influence of pancreas transplantation on cardiorespiratory reflexes, nerve conduction, and mortality in diabetes mellitus. Diabetes, 39, 802–806.PubMedCrossRefGoogle Scholar
  34. Novick, R.J., Stitt, L., Al-Kattan, K., Klepetko, W., Schafers, H.J., Duchatelle, J.P., Khaghani, A., Hardesty, R.L., Patterson, G.A., & Yacoub, M.H. (1998). Pulmonary retransplantation: Predictors of graft function and survival in 230 patients: Pulmonary retransplant registry. Annals of Thoracic Surgery, 65, 227–234.PubMedCrossRefGoogle Scholar
  35. Oyer, P.E., Stinson, E.B., Jamieson, S.W., Hunt, S.A., Reitz, B.A., Bieber, C.P., Schroeder, J.S., Billingham, M.E., & Shumway, N.E. (1982). One year experience with cyclosporine A in clinical heart transplantation. Heart Transplantation, 1, 285–290.Google Scholar
  36. Paris, W.P., Diercks, M., Bright, J., Zamora, M., Kesten, S., Scavuzzo, M., & Paradis, I. (1998). Return to work after lung transplantation. Journal of Heart and Lung Transplantation, 17, 430–436.PubMedGoogle Scholar
  37. Pham, S.M., Keenan, R.J., & Griffith, B. (1996). New approaches to achieve immunologic acceptance of lung allografts. Seminars in Respiratory and Critical Care Medicine, 17, 197–205.CrossRefGoogle Scholar
  38. Rappaport, F. (1991). The life and times of a transplant immunosurgeon. In P. Terasaki (ed.), History of transplantation: Thirty-five recollections (pp. 349–378). Los Angeles, CA: UCLA Tissue Typing Laboratory.Google Scholar
  39. Rogiers, X., Malago, M, Habib, N., Knoefel, W.T., Pothmann, W., Burdelski, M., Meyer-Moldenhauer, W.H., & Broelsch, C.E. (1995). In situ splitting of the liver in the heart-beating cadaveric organ donor for transplantation in two recipients. Transplantation, 59, 1081–1083.PubMedGoogle Scholar
  40. Sachs, D. (1999). Mechanisms of immunological tolerance, especially in humans and primates. Paper presented at the 25th Annual Meeting of the American Society of Transplant Surgeons. Chicago, IL.Google Scholar
  41. Schnitzler, M. (1999). Economic cost of expanded criteria donors in cadaveric renal transplantation. Paper presented at the 25th Annual Meeting of the American Society of Transplant Surgeons. Chicago, IL.Google Scholar
  42. Schnuelle, P., Lorenz, D. & Trede, M. (1998). Impact of renal cadaveric transplantation on survival in end-stage renal failure: Evidence for reduced mortality risk compared with hemodialysis during long-term follow-up. Journal of the American Society of Nephrology, 9, 2135–2141.PubMedGoogle Scholar
  43. Starnes, V.A., Barr, M.L., Cohen, F.A., Schenkel, F.A., Barbers, R.G. and the USC Transplant Group. (1994). Bilateral living-related lobar transplantation for cystic fibrosis: Initial experience. Journal of Heart and Lung Transplantation, 13, S57.Google Scholar
  44. Starzl, T., Marchioro, T.L., von Kaulla, K.N., Hermann, G., Brittain, R.S., & Waddell, W.R. (1963). Homotransplantation of the liver in humans. Surgery, Gynecology & Obstetrics, 117, 659–676.Google Scholar
  45. Starzl, T., Klintmalm, G., Porter, K., Iwatsuki, S., & Schroter, G.P.J. (1981). Liver transplantation with the use of cyclosporine A and prednisone. New England Journal of Medicine, 305, 266–269.PubMedCrossRefGoogle Scholar
  46. Stevenson, L.W. (1994). Selection and management of patients for cardiac transplantation. Currernt Opinions in Cardiology, 9, 315–325.CrossRefGoogle Scholar
  47. Stinson, E.B., Dong, E., Bieber, C.P., Popp, R.L., & Shumway, N.E. (1969). Cardiac transplantation in man: II. Immunosuppressive therapy. Journal of Thoracic and Cardiovascular Surgery, 58, 326–337.PubMedGoogle Scholar
  48. Stinson, E.B., Dong, E., Bieber, C.P., Schroeder, J.S., & Shumway, N.E. (1969). Cardiac transplantation in man: I. Early rejection. Journal of the American Medical Association, 207, 2233–2247.PubMedCrossRefGoogle Scholar
  49. Sutherland, D. (1999). International pancreas transplant registry. Minneapolis, MN: Department of Surgery, University of Minnesota.Google Scholar
  50. Tapson, V.F., & Baz, M.A. (1998). Lung transplantation. In G.L. Baum, J.D. Crapo, B.R. Celli, & J.B. Karlinsky (eds.), Textbook of pulmonary diseases. Philadelphia, PA: Lippincott-Raven Publishers.Google Scholar
  51. United Network for Organ Sharing (UNOS). (2000). Scientific registry data - 1998. Richmond, VA.: Department of Health and Human Services.Google Scholar
  52. Wahlberg, J., Love, R., Landegaard, L., Southard, J.H., & Belzer, F.O. (1987). 72 hour preservation of the canine pancreas. Transplantation, 43, 5–8.PubMedCrossRefGoogle Scholar
  53. Williams, G., (1988). Results of kidney transplantation. In G. Cerilli (ed.), Organ transplantation and replacement. Philadelphia: J.B. Lippincott.Google Scholar
  54. Young, J.B. (1998). Historical overview of heart transplantation. In D.J. Norman & W.N. Suki (eds.), Primer on transplantation. Thorofare, NJ: American Society of Transplant Physicians.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Alan Reed
  • Maher A. Baz
  • LeAnne McGinn
  • Richard S. Schofield

There are no affiliations available

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