The Cell Biology of Coronavirus Infection
Several aspects of Coronavirus interaction with host cells have been identified, the best characterized of which involve virus entry and virion assembly (for review, see Holmes and Lai, 1996). These accomplishments are critical in the understanding of virus-cell interactions; however, since such interactions occur in four dimensions (over time in the three dimensional space of the cell) they are important landmarks on a path that for the most part remains unilluminated. To understand the dynamic relationship of the virus to the cell it is important to use approaches that can observe interactions in the context of the entire cell and throughout the course of infection.
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